Prognostic value of glucose transporter proteins-1 (GLUT1) in breast carcinoma

Figures & data

Table 1. Clinicopathological characteristics of breast cancer patients overall and by levels of GLUT1 immunoexpression.

		GLUT staining, N (%)
Variable	Overall sample	No staining, 267 (46)	Low, 140 (24)	High, 171 (30)	P-value
Age (years), Mean±SD	50.4 ± 13.4	50.7 ± 13.3	49.9 ± 13.7	50.4 ± 13.3	0.86
Tumor size, N (%)					0.36
<3 cm	190 (38.6)	92 (41.3)	48 (41.4)	50 (32.7)
3–6 cm	237 (48.2)	103 (46.2)	56 (48.3)	78 (51.0)
>6 cm	65 (13.2)	28 (12.6)	12 (10.3)	25 (16.3)
Lymph node metastasis, N (%)					0.67
No LN metastasis	181 (37.3)	86 (37.1)	46 (40.4)	49 (35.3)
1–3 Lymph nodes	142 (29.3)	71 (30.6)	34 (29.8)	37 (26.6)
>3 Lymph nodes	162 (33.4)	75 (32.3)	34 (29.8)	53 (38.1)
Distant metastasis, N (%)	77 (13.3)	33 (12.4)	19 (13.6)	25 (14.6)	0.79
Tumor invasion, N (%)	512 (96.8)	236 (96.3)	128 (96.2)	148 (98.0)	0.60
Vascular invasion, N (%)	176 (43.7)	65 (37.4)	56 (52.3)	55 (45.1)	0.045
Histological type, N (%)					0.86
Ductal	512 (89.5)	234 (89.3)	127 (90.7)	151 (88.8)
Others	60 (10.5)	28 (10.7)	13 (9.3)	19 (11.2)
Tumor grade, N (%)					<0.0001
Grade 1	83 (16.6)	56 (24.8)	15 (12.0)	12 (8.0)
Grade 2	257 (51.3)	121 (53.5)	75 (60.0)	61 (40.7)
Grade 3	161 (32.1)	49 (21.7)	35 (28.0)	77 (51.3)
Positive ER, N (%)	304 (66.4)	161 (76.3)	73 (67.0)	70 (50.7)	<0.0001
Positive PR, N (%)	271 (59.3)	144 (68.2)	71 (65.1)	56 (40.9)	<0.0001
Positive HER2, N (%)	170 (39.2)	71 (35.3)	45 (45.9)	54 (40.0)	0.21
Died of disease, N (%)	61 (10.6)	30 (11.2)	17 (12.1)	14 (8.2)	0.47
Recurrence, N (%)	74 (24.0)	33 (23.1)	19 (23.5)	22 (26.2)	0.86

Figure 1. Cytoplasmic expression of GLUT1 in breast cancer. a: negative stain (20X); b: weak positive stain (20 X); c: moderate positive stain (20 X); d: strong positive stain (20X).

Table 2. Odds ratios (95% CI) of the association between histopathological characteristics and GLUT1 immunoexpression level×.

Variable	OR (95% CI)	P-value
Tumor grade (reference = Grade 1)	1
Grade 2	2.18 (1.31, 3.61)	0.003
Grade 3	5.33 (3.11, 9.15)	0.0001
Vascular invasion	1.35 (0.93, 1.94)	0.11
Positive ER	0.40 (0.28, 0.58)	0.0001
Positive PR	0.42 (0.30, 0.60)	0.0001
Positive HER2	1.22 (0.85, 1.75)	0.28

*Each characteristic was modelled separately.