Relationship between serum Midkine and Omentin-1 levels and the severity of sepsis in patients and their prognostic value

Figures & data

Figure 1. Sepsis Case Flow Chart.

Table 1. Comparison of baseline variables among the three groups.

Variate	SEP group (n = 76)	Severe SEP group (n = 59)	SEP shock group (n = 45)	t/${\chi }^2$	P
Age (year)	48.54 ± 4.96	49.32 ± 5.08	50.24 ± 5.17	1.617	0.201
Gender
male	39 (51.32)	28 (47.46)	24 (53.33)	0.383	0.826
female	37 (48.68)	31 (52.54)	21 (46.67)
BMI (kg/m^2)	22.49 ± 3.26	23.12 ± 3.47	22.78 ± 3.32	0.589	0.556
Smoking history
Yes	21 (27.63)	17 (28.81)	15 (33.33)	0.459	0.795
No	55 (72.37)	42 (71.19)	30 (66.67)
Drinking history
Yes	24 (31.58)	19 (32.20)	17 (37.78)	0.539	0.764
No	52 (68.42)	40 (67.80)	28 (62.22)
TC (mmol/L)	4.76 ± 0.87	4.84 ± 0.91	5.03 ± 0.95	1.272	0.283
TG (mmol/L)	1.65 ± 0.52	1.74 ± 0.55	1.83 ± 0.54	1.637	0.198
Midkine (ng/mL)	0.68 ± 0.17	1.19 ± 0.18^a	1.87 ± 0.19^ab	631.436	≤0.000
Omentin-1 (ng/mL)	83.74 ± 8.46	62.51 ± 8.04^a	45.26 ± 7.75^ab	329.248	≤0.000
APACHEII score (score)	11.28 ± 1.62	14.57 ± 1.73^a	17.36 ± 1.81^ab	186.921	≤0.000

TC : total cholesterol, TG: triglyceride, Compared with SEP group, ^ap < 0.05; Compared with severe SEP group, ^bp < 0.05.

Table 2. Comparison of baseline variables based on the prognosis of sepsis patients.

Variate	Survival group (n = 128)	Death group (n = 52)	t/${\chi }^2$	P
Age (years)	48.84 ± 4.99	50.16 ± 5.24	1.585	0.115
Gender
male	63 (49.22)	28 (53.85)	0.317	0.574
female	65 (50.78)	24 (46.15)
BMI (kg/m^2)	22.65 ± 3.29	23.07 ± 3.42	0.767	0.444
Smoking history
Yes	34 (26.56)	19 (36.54)	1.771	0.183
No	94 (73.44)	33 (63.46)
Alcohol use history
Yes	41 (32.03)	19 (36.54)	0.338	0.561
No	87 (67.97)	33 (63.46)
TC (mmol/L)	4.78 ± 0.89	5.02 ± 0.93	1.619	0.107
TG (mmol/L)	1.68 ± 0.54	1.82 ± 0.57	1.551	0.123
Midkine (ng/mL)	1.03 ± 0.28	1.41 ± 0.32	7.913	≤0.000
Omentin-1 (ng/mL)	70.14 ± 8.43	59.82 ± 7.94	7.568	≤0.000
APACHEII score (score)	12.73 ± 1.72	16.71 ± 1.79	13.907	≤0.000

TC: total cholesterol, TG: triglyceride.

Table 3. Analysis of factors influencing the prognosis of sepsis patients.

Affecting factors	β	SE	Wald	P	OR	95%CI
Midkine	1.168	0.348	11.262	0.001	3.215	1.625 ~ 6.359
Omentin-1	−0.323	0.097	11.086	0.001	0.724	0.599 ~ 0.876
APACHE II score	0.950	0.301	9.964	0.002	2.586	1.434 ~ 4.665

Figure 2. ROC Curves for Predicting the Prognosis of Sepsis Patients Using Serum Midkine and Omentin-1 Levels.

Table 4. Predictive value of serum midkine and omentin-1 levels for the prognosis of sepsis patients.

Variate	AUC	cutoff value	95%CI	Sensibility (%)	Specificity (%)	Youden index	P
Midkine	0.842	1.17 ng/mL	0.780 ~ 0.892	82.69	73.44	0.561	0.000
Omentin-1	0.783	64.73 ng/mL	0.715 ~ 0.841	71.15	75.00	0.462	0.000
Combination of the two	0.880	–	0.823 ~ 0.923	90.38	72.66	0.630	0.000

Data availability statement

The original contributions presented in the study are included in the article.