Human cytomegalovirus is present in the odontogenic epithelium of ameloblastoma

Figures & data

Table 1. Clinical features of the studied cases

Variables	Total	Dentigerous cyst	Odontogenic keratocyst	Ameloblastoma
Patients (n)	41	13	12	16
Age (years) Mean Range	37.24 12–74	40 12–74	39.42 15–66	33.38 12–70
Gender, n (%) Male Female	23 (56.1%) 18 (43.9%)	10 (76.9%) 3 (23.1%)	5 (41.7%) 7 (58.3%)	8 (50%) 8 (50%)
Location, n (%) Mandible Maxilla	26 (63.4%) 15 (36.6%)	3 (23.1%) 10 (76.9%)	8 (66.7%) 4 (33.3%)	15 (93.8%) 1 (6.3%)

Table 2. The presence of HCMV-DNA and the expression of HCMV-gB in the studied groups

Samples	HCMV-DNA	HCMV-gB
Dentigerous cyst (n= 13)	+ve (n= 4) 30.8% -ve (n= 9) 69.2%	+ve (n= 2) 15.4% -ve (n= 11) 84.6%
Odontogenic Keratocyst (n= 12)	+ve (n= 3) 25% -ve (n= 9) 75%	+ve (n= 0) 0.0% -ve (n= 12) 100%
Ameloblastoma (n= 16)	+ve (n= 10) 62.5% -ve (n= 6) 37.5%	+ve (n= 12) 75% -ve (n= 4) 25%

Figure 1. Immunohistochemical expression of HCMV-gB in the studied odontogenic lesions. The positively stained cells in dentigerous cyst were distributed throughout the epithelial wall (A), absence of staining in odontogenic keratocyst (B), negative staining in ameloblastoma (AB) (C), heavy expression of HCMV-gB in both the peripheral columnar cells and the stellate reticulum‒like cells of AB (D), more positive expression in the peripheral columnar cells of AB (E), and (F) more positive expression in the stellate reticulum‒like cells of AB