The secretion of cytokines by peripheral blood mononuclear cells of patients with periodontitis and healthy controls when exposed to H₂S

Figures & data

Table 1. The median secretion (pg/mL) of the examined markers

Marker	Healthy		p-value	Periodontitis		p-value
	Cells	Cells±NaHS		Cells	Cells±NaHS
TNF-α	55.9 (59.1)	94.4 (317)	0.0004	95.3 (101)	141 (298)	0.001
IFN- γ	15.8 (11.2)	24.7 (75.5)	0.0007	28.23 (36.9)	48.5 (82.2)	0.003
IL-6	53.6 (37.2)	320 (1560)	<0.0001	150 (248)	536 (1790)	0.0009
IL-8	6 780 (14,900)	6 090 (16,700)	0.814	0 (13,600)	0 (4 600)	0.542
IL-12p40	0 (0)	0 (0)	0.030	0 (0)	0 (25.3)	0.0005
IL-12p70	0 (0)	0 (0.65)	0.008	0 (0.48)	0.41 (0.91)	0.006
IL-17	0.66 (0.92)	0.91 (2.63)	0.0005	1.03 (0.89)	1.87 (3.11)	0.0001
MCP-1	190 (355)	402 (511)	0.006	603 (547)	573 (640)	0.885
IL-1Ra	753 (1090)	390 (757)	0.0001	746 (1370)	644 (1110)	0.094

The data are presented as medians (interquartile range). Wilcoxon matched-pairs signed-rank test was used to compare the two groups (cells vs cells+NaHS).

Figure 1. Secretion of cytokines by PBMCs. The secretions of IFN- γ, IL-6, IL-17, TNF-α, IL-12p40, IL-12p70, MCP-1, IL-8, and IL-1Ra of resting PBMCs and PBMCs exposed to NaHS from patients with periodontitis and healthy controls. The median is shown as a vertical line (IFN- γ: 1.20 and 1.39 for healthy, 1.45 and 1.69 for periodontitis. IL-6: 1.73 and 2.51 for healthy, 2.18 and 2.73 for periodontitis. IL-17: 0 and 0 for healthy, 0.02 and 0.27 for periodontitis TNF-α: 1.75 and 1.98 for healthy, 1.98 and 2.15 for periodontitis. IL-12p40: 0 and 0 for healthy, 0 and 0 for periodontitis. IL-12p70: 0 and 0 for healthy, 0 and 0 for periodontitis. MCP-1: 2.28 and 2.60 for healthy, 2.78 and 2.76 for periodontitis. IL-8: 3.83 and 3.78 for healthy, 0 and 0 for periodontitis. IL-1Ra: 2.88 and 2.59 for healthy, 2.87 and 2.81 for periodontitis)