Survival after lymphadenectomy of nodal metastases from melanoma of unknown primary site

Figures & data

Table 1. Pre-operative characteristics (n = 864).

Characteristics	MUP (n = 113)		MKP (n = 627)
	St III (n = 93)	St IV (n = 20)	St III (n = 627)	St IV (n = 124)
Gender
Male	52 (56%)	11 (55%)	369 (59%)	44 (35%)
Female	41 (44%)	9 (45%)	258 (41%)	80 (65%)
Age at surgery, years	62 (25–90)	62 (37–83)	61 (13–95)	65 (30–93)
BMI^a	26 (17–41)	24 (19–33)	26 (19–33)	25 (18–37)
Duration of surgery, minutes^a	106 (60–240)	110 (66–260)	95 (30–540)	133 (55–252)
Nodal station
Neck	9 (10%)	2 (10%)	73 (12%)	21 (17%)
Axilla	43 (46%)	15 (75%)	269 (43%)	56 (45%)
Groin	40 (43%)	3 (15%)	275 (44%)	46 (37%)
Pelvic	1 (1%)	0	7 (1%)	1 (1%)
Pre-op diagnosis
US/FNAC	39 (42%)	7 (35%)	472 (75%)	81 (65%)
Biopsy	22 (24%)	7 (35%)	38 (6%)	9 (7%)
Node picking	28 (30%)	3 (15%)	98 (16%)	21 (17%)
Previously nodal dissection	4 (4%)	3 (15%)	19 (3%)	13 (11%)

^aMedian and range.

Table 2. Stage III, post-operative characteristics.

Stage III
Characteristics	MUP n = 93	MKP n = 632	Univariate	Univariate	Multivariate	Multivariate
			HR (95% CI)	p Value	HR (95% CI)	p Value
Number of affected nodes^a	1 (1–25)	2 (0–74)	1.72 (1.301–2.200)	p < 0.001	1.69 (1.326–3.072)	p < 0.001
Tumour size^a,b	45 (11–140)	30 (7–150)	1.00 (1.000–1.011)	p < 0.001	1.01 (1.001–1.009)	p = 0.040
Perinodal growth
Yes	29 (31%)	246 (39%)	0.55 (0.463–0.671)	p < 0.001	0.69 (0.570–0.853)	p < 0.001
No	63 (68%)	370 (58%)
Unknown	1 (1%)	16 (3%)
Affected nodal basins^c
1	73	512	0.97 (0.860–1.104)	p = 0.689	0.88 (0.778–1.006)	p = 0.063
2	18	106
3	2	14

^aMedian and range.

^bMillimetres.

^cNumber of patient.

HR: Hazard Ratio; CI: Confidence Interval.

Table 3. Stage IV, post-operative characteristics.

Stage IV
Characteristics	MUP n = 20	MKP n = 124	Univariate HR (95% CI)	Univariate p Value	Multivariate HR (95% CI)	Multivariate p Value
Number of affected nodes	4 (1–60)	2 (1–50)	1.30 (0.728–2.351)	p = 0.380	1.38 (0.691–1.984)	p = 0.288
Tumour size^a,b	44 (15–230)	41 (4–220)	1.00 (1.003–1.10)	p < 0.001	1.00 (1.001–1.010)	p < 0.004
Perinodal growth
Yes	9 (45%9	71 (60%)	0.61 (0.427–0.880)	p = 0.008	0.70 (0.472–1.053)	p = 0.088
No	10 (50%)	40 (34%)
Unknown	1 (5%)	8 (7%)
Affected nodal basins^c
1	19	108	0.80 (0.540–1.212)	p = 0.306	0.85 (0.536–1.361)	p = 0.509
2	1	10
3	0	1

^aMedian and range.

^bMillimetres.

^cNumber of patients.

HR: Hazard Ratio; CI: Confidence Interval.

Figure 1. Five-year survival for stage III for MUP and MKP (p = 0.022).

Figure 2. Five-year survival for stage IV for MUP and MKP (p = 0.151).

Figure 3. Five-year RFS for MUP and MKP (p = 0.049).