Interpersonal psychotherapy versus sertraline for women with posttraumatic stress disorder following recent sexual assault: a randomized clinical trial

Figures & data

Figure 1. Clinical trial flow chart.

Table 1. Baseline sociodemographic characteristics of each intervention group.

	Sertraline	IPT-PTSD	Total
Age avg (±SE)	24.6 (7.1)	25.2 (6.5)	24.8(6.8)
Race
White	16	16	32
Mixed race	14	15	29
Black	5	7	12
Asian	0	1	1
Civil Status
Single	20	30	50
Married	14	8	22
Divorced	1	1	2
Education level
Less than High-School	21	17	38
High-School or more	14	22	36
Childhood sexual abuse (yes)	7	7	14*
CTQ*** – avg score (±SE)	38.5 (14.7)	33 (17.2)	36 (16.0)
Income (Real**)
Avg per month (±SE)	1063 (1418)	1196 (1169)	1138 (1276)

*There was one participant with missing data.

**1 US Dollar∼5 Real.

***CTQ (Childhood Trauma Questionnaire).

Table 2. Clinical outcomes across four-time points by intervention groups.

Time-point		Baseline		4-week		8-week		14-week
Treatment	Scale	N	Mean (SD)	N	Mean (SD)	N	Mean (SD)	N	Mean (SD)
Sertraline	CAPS	35	42.49 (9.36)	23	36.17 (13.46)	21	32.71 (14.3)	19	27.11 (15.85)
	CGI	33	4.91 (0.8)	22	4.41 (1.14)	22	3.77 (1.31)	17	3.59 (1.37)
	BDI	34	29.15 (10.99)	23	21.61 (11.87)	24	16.63 (9.85)	19	15.37 (12.51)
	BAI	34	27.44 (10.88)	23	23.35 (15.09)	24	22.67 (13.85)	18	19.94 (15.09)
IPT	CAPS	39	42.59 (9.08)	25	42.6 (10.9)	24	32.29 (13.58)	26	29.12 (15.46)
	CGI	38	4.89 (0.8)	24	4.33 (0.76)	21	3.76 (1.22)	26	3.69 (1.01)
	BDI	39	28.31 (11.72)	26	24.12 (9.42)	25	17 (11.51)	26	17.23 (17.21)
	BAI	39	29.33 (11.72)	25	27.56 (14.1)	25	23.64 (17.17)	26	21.15 (12.9)

Table 3. Unstandardized effects of group and time for two different GEEs effects after adjusting for age, therapists and supplemental medication use across the four time points.

		Outcome	Group difference	95% CI		p-value	Time	95% CI		p-value	Group *Time interaction	95% CI		p-value
Unconditional Model	GEE-FIML	CAPS-5	1.73	2.80	6.26	.453	−7.55	−9.51	−5.59	.001
	Full-information Maximum Likelihood	CGI	0.19	0.23	0.62	.37	−0.52	−0.73	−0.32	<.001
		BDI	0.96	4.09	6.01	.71	−5.98	−7.59	−4.37	<.001
		BAI	−0.23	5.78	5.32	.93	−4.25	−6.00	−2.49	<.001
	GEE-MI	CAPS-5	0.76	4.14	4.29	.97	−7.43	−9.29	−5.57	<.001
		CGI	0.08	0.27	0.44	.66	−0.48	−0.66	−0.30	<.001
		BDI	−0.35	4.71	4.02	.88	−5.06	−6.79	−3.33	<.001
		BAI	−1.44	6.32	3.44	.56	−4.10	−6.35	−1.86	<.001
Conditional Model	GEE-FIML	CAPS-5	0.01	5.28	5.30	1.00	−7.94	−10.60	−5.29	<.001	0.78	2.015	3.575	.584
	Full-information Maximum Likelihood	CGI	0.13	4.26	0.68	.66	−0.54	−0.79	−0.29	<.001	0.03	−0.27	0.34	.84
		BDI	2.80	3.73	9.33	.40	−5.56	−7.76	−3.36	<.001	−0.83	−3.25	1.60	.50
		BAI	−0.44	7.28	6.41	.90	−4.29	−6.63	−1.95	<.001	0.09	−2.74	2.92	.95
	GEE-MI	CAPS-5	0.91	4.97	6.78	.76	−7.27	−9.63	−4.90	<.001	−0.34	−2.98	2.30	.80
		CGI	0.16	0.46	0.71	.59	−0.46	−0.67	−0.26	<.001	−0.03	0.13	−0.28	.81
		BDI	2.56	4.33	9.46	.47	−4.48	−6.54	−2.43	<.001	−1.18	−3.66	1.29	.35
		BAI	−0.67	8.04	6.70	.86	−3.95	−6.53	−1.37	.003	−0.32	−3.10	2.47	.82

Note: CI = confidence interval; CGI = Clinical Global Impression; BDI = Beck Depression Inventory; BAI = Beck Anxiety Inventory; MI = multiple imputation.

Data availability statement

The data that support the findings of this study are openly available in Mendeley Data at https://data.mendeley.com/v1/datasets/nfw294mnn3/draft?preview=1.