Figures & data
Figure 1. How FKBP5 genotype may shape risk vs. resilience to exposure to adversity during childhood. In the light of adversity, the genotype effect is unmasked and needs additional epigenetic changes at the FKBP5 locus to occur. This leads to a transcriptional disinhibition of FKBP5 and high FKBP5 levels, associated with increased anxiety and decreased stress coping. A combined FKBP5 risk genotype and exposure to childhood trauma has been associated with risk for a number of psychiatric disorders, suggesting that patients with high FKBP5 could represent a transdiagnostic subtype of patients who could benefit from common treatment strategies, such as FKBP5 antagonists.
