Antibody responses to tick-borne encephalitis virus non-structural protein 1 and whole virus antigen–a new tool in the assessment of suspected vaccine failure patients

Figures & data

Figure 1. (a) Number of sold TBE vaccine doses in Sweden 2001-2018. (b) Number of notified TBE cases in Sweden 1999-2018.

Source: The Public Health Agency of Sweden.

Table 1. Summary of results for each vaccination failure patient.

Patient No.	Age at disease (years)	Sex	Number of vaccine doses	Time from last vaccine dose to disease	No of sampling points^a	Neutralization titer	IgM and IgG antibodies to WV antigen in sera	IgM antibodies to NS1 antigen in sera or CSF	IgM antibodies to NS1 antigen in sera alone
1	63	Male	4	2 years	2	10, >160	Positive	Positive	Negative
2	67	Male	3	2 years	1	640	Positive	Positive	Positive
3	39	Male	2	3 months	1	80	Positive	Positive	Positive
4	21	Male	2	5 months	1	40–80	Positive	Positive	Positive
5	6	Male	3	1 year	1	>160	Positive	Positive	Positive
6	67	Female	3	Unknown	2	640, 1280	Positive	Positive	Positive
7	55	Female	2	4 months	1	160	Positive	Positive	Positive
8	52	Female	5	3 years	1	5	Positive	Negative	Negative
9	68	Male	4	5 months	1	80	Positive	Positive	Positive
10	64	Male	3	1 year	2	20, 80	Positive	Positive	Positive
11	74	Male	4	3 years	1	160	Positive	Positive	Positive
12	62	Male	4	3 years	1	n.d.	Positive	Negative	Negative
13	72	Male	3	1 year	1	320	Positive	Positive	Positive
14	76	Male	3	2 years	1	80–160	Positive	Negative	Negative
							14/14	11/14	10/14

^aThree patients had more than one sample. Only one of the sampling points has been scored for each patient. See the Results section for more detailed explanation.