An investigation of household dogs as the source in a case of human bacteraemia caused by Staphylococcus pseudintermedius

Figures & data

Table 1. Minimum inhibitory concentration (MIC), mg/L, to tested antibiotics of S. pseudintermedius isolates from blood culture from the male patient and two dogs residing in his household. MIC determined using broth-microdilution and the SensititreTM EUST and STAFSTR panels. CLSI break-point for Staphylococci** (VEY01S) and EUCAST Epidemiological cut-offs (ECOFFs) (mic.Eucast.org).

		Chloramphenicol	Gentamicin	Kanamycin	Streptomycin	Rifampicin	Cefoxitin	Cephalothin	Oxacillin (NaCl)	Penicillin G	Fusidic Acid	Vancomycin	Clindamycin	Erythomycin	Mupirocin	Nitrofurantoin	Linezolid	Ciprofloxacin	Enrofloxacin	Tiamulin	Quinupristin/dalfopristin	Sulfamethoxazole	Trimethoprim	Trimethoprim/Sulfamethoxazole	Tetracycline
	CLSI break-points	Human ≥8	Human ≥16	NA	NA	NA	NA	≥8**	≥0.5**	NA	NA	Human ≥32	Dogs ≥4	NA	NA	Human ≥128	NA	NA	Dogs ≥4	NA	NA	NA	NA	Human ≥4/76	Human ≥16 dogs ≥1
	EUCAST ECOFFs	NA	>0.25	NA	NA	NA	NA	NA	NA	>0.03	NA	NA	>0.25	>0.5	NA	NA	NA	NA	>0.5	NA	NA	NA	NA	NA	>0.5
Strain ID	Origin
AB4107	Patient	8	≤1	≤4	≤4	≤0.016	0.5*	≤1*	≤0.25*	0.06*	≤0.5	≤1	≤0.12	≤0.25	≤0.5	≤16*	≤1	≤0.25	≤0.25*	≤0.5	≤0.5	256	≤2	0.5*	≤0.25*
AB4116	Dog 1	8	≤1	64	>32	≤0.016	≤0.25*	≤1*	≤0.25*	0.12*	4	≤1	>4	>8	≤0.5	≤16*	≤1	≤0.25	≤0.25*	≤0.5	≤0.5	256	≤2	0.5*	≤0.25*
AB4118	Dog 2	8	≤1	64	>32	≤0.016	≤0.25*	≤1*	≤0.25*	0.25*	4	≤1	>4	>8	≤0.5	≤16*	≤1	≤0.25	≤0.25*	≤0.5	≤0.5	256	≤2	0.5*	≤0.25*

*MIC determined by the STAFSTR panel, ** = S. pseudintermedius specific breakpoint.

Data availability statement

The data that support the findings of this study are available from the corresponding authors, [ÅÖB and SB], upon reasonable request. Sequence data is available from the European Nucleotide Archive under project accession number PRJEB56536, https://www.ebi.ac.uk/ena/browser/view/PRJEB56536.