Successful rapid oral desensitization for dual hypersensitivity to isoniazid and rifampin while treating central nervous system tuberculosis

Figures & data

Figure 1. MRI showing diffuse leptomeningeal enhancement.

Table 1. Cerebrospinal fluid analysis result.

CSF RBC	530
Total Nucleated cell	65
Neutrophils	9%
Lymphocytes	84%
Monocytes	6%
Protein	1500mg/dl
Glucose	48 mg/dl

Table 2. Isoniazid desensitization.

Serial	dose	time
1	0.1 mg	0800
2	0.5 mg	0830
3	1 mg	0900
4	2 mg	0930
5	4 mg	1000
6	8 mg	1030
7	16 mg	1100
8	32 mg	1130
9	50 mg	1200
10	100 mg	1300
11	150 mg	1400
12	200 mg	1500

Table 3. Rifampin desensitization.

Serial	Dose	Time
1	0.1 mg	0800
2	0.5 mg	0830
3	1 mg	1000
4	2 mg	1100
5	4 mg	1145
6	8 mg	1245
7	16 mg	1345
8	32 mg	1445
9	50 mg	1545
10	100 mg	1645
11	150 mg	1745
12	225 mg	1845
13	450 mg	2230