Extracellular vesicles circulating in young organisms promote healthy longevity

Figures & data

Figure 1. Chronic treatment with extracellular vesicles of young mice prolongs lifespan in old mice. (a) The amount of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) within extracellular vesicles (EVs) decreases during ageing, while the content of senescence-associated (SA)-miRNAs increases progressively. (b) EVs isolated from plasma of young mice contain high levels of eNAMPT and low levels of SA-miRNAs. EVs from young mice injected intraperitoneally into old mice once-a-week produce a tangible increase in lifespan coupled by an enhanced physical activity and a healthier aspect [16]. Shuttled eNAMPT is functionally active in receiving tissues, thus increasing NAD+ levels and pushing SIRT1 activation. Low-levels of SA-miRNAs promote a higher SIRT1 expression [15], implying that young EVs may concertedly sustain SIRT1-related pathways, ultimately promoting healthy longevity.

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