Economic burden for Alzheimer’s disease in China from 2010 to 2050: a modelling study

Figures & data

Table 1. Total number of AD patients and total population.

	2010	2020	2030	2040	2050
Total population in China (million)	1,336.7	1,394.0	1,403.9	1,364.7	1,301.6
Total number of AD patients (million)	5.8	9.0	13.0	17.6	21.1
Percentage of AD patients in total population	0.4%	0.6%	0.9%	1.3%	1.6%

AD: Alzheimer’s disease

Table 2. Resource use input in every 6-month cycle.

	Moderate Independent Non-Aggressive	Moderate Independent Aggressive	Moderate Dependent Non-Aggressive	Moderate Dependent Aggressive	Severe Independent Non-Aggressive	Severe Independent Aggressive	Severe Dependent Non-Aggressive	Severe Dependent Aggressive
Treated patients
Pharmacological treatment (day of use)	180	180	180	180	180	180	180	180
Consultations (number of use)	6	6	6	6	6	6	6	6
Biological analysis (number of use)	1	1	1	1	1	1	1	1
Brain imaging (number of use)	0	0	0	0	0	0	0.35	0.35
Cognitive assessment scales (number of use)	1	1	1	1	0	0	0	0
Hospitalisations (probability)	0%	5%	5%	90%	1%	1%	35%	70%
Nursing home (probability)	0%	20%	80%	0%	0%	20%	80%	20%
Other caregiver time (hours per day)	1	3	4	10	1	3	12	15
Untreated patients
Hospitalisations (probability)	0%	1%	1%	18%	0.2%	0.2%	7%	14%
Nursing home (probability)	0%	4%	16%	0%	0%	4%	16%	4%
Other caregiver time (hours per day)	1	3	4	10	1	3	12	15

Table 3. Cost input for treated in every 6-month cycle (RMB).

Resource use	Unit price	Base case	Lower	Higher	Source
Treated patients
Treatment	per day	12.7	3.2	22.2	IMS data
Consultations	per consultation	236	123	441	Annual report 2016[^18]
Biological analysis	per use	500	500	500	Yu 2015[^16]
Brain imaging	per use	1,050	1,050	1,050	Yu 2015[^16]
Cognitive assessment scales	per use	100	100	100	Yu 2015[^16]
Hospitalisation for moderate AD	per admission	1,600	1,600	1,600	Yu 2015[^16]
Hospitalisation for severe AD	per admission	37,087	29,670	44,505	Yang 2017[^19]
Nursing home	per month	6,000	3,000	6,000	Yu 2015[^16]
Professional caregiver	per month (8 hour/day)	6,000	6,000	6,000	Yu 2015[^16]
Untreated patients
Hospitalisation for moderate AD	per admission	1,600	1,600	1,600	Yu 2015[^16]
Hospitalisation for severe AD	per admission	8,268	5,388	20,149	Annual report 2016[^18]
Nursing home (24 hour/day)	per month	3,000	1,000	6,000	Yu 2015[^16]
Professional caregiver	per month (8 hour/day)	6,000	6,000	6,000	Yu 2015[^16]

AD: Alzheimer’s disease

Figure 1. Clinical characteristics of AD patients at model entry and after 5 years.

Figure 2. Evolution of annual costs related to AD patients.

Figure 3. Estimated costs in 2050 with different scenarios of treatment rate.

2016 annual statistics report of China health and family planning commission. China Peking Union Medical University Press; [cited 2017 Oct 08]. Available from http://cnki.heinfo.gov.cn/csydkns/navi/YearBook.aspx?id=N2015110062&floor=1

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