The impact of amortization of gene therapies funding on the results and conclusions of CEMs and BIMs

Figures & data

Table 1. Scenarios implemented.

	Scenarios
	Base case	AMORTIZATION DURATION			DISCOUNTING RATE
		SCENARIO A1	SCENARIO A2	SCENARIO A3	SCENARIO B1	SCENARIO B2	SCENARIO B3
Amortization duration	5 years	3 years	7 years	10 years	5 years
Discounting rate	3%	3%			1%	5%	7%

Table 2. CEM base case results.

CEM
Intervention cost & amortization
No amortization	Amortization	Cost difference
$850,000	$791,145	-$58,855

Table 3. CEM scenarios results.

	Scenario A1	Scenario A2	Scenario A3	Scenario B1	Scenario B2	Scenario B3
No amortization	$850,000	$850,000	$850,000	$850,000	$850,000	$850,000
Amortization	$814,404	$768,773	$736,796	$829,546	$755,796	$723,189

Table 4. Total budget impact results for base case and scenarios A1-A3.

No amortization
Year 1	Year 2	Year 3	Year 4	Year 5	Total
$850,000	$0.00	$0.00	$0.00	$0.00	$850,000
Base case
Amortization
Year 1	Year 2	Year 3	Year 4	Year 5	Total
$170,000	$170,000	$170,000	$170,000	$170,000	$850,000
3 years
Amortization
Year 1	Year 2	Year 3	Year 4	Year 5	Total
$283,333	$283,333	$283,333	$0.00	$0.00	$850,000
7 years
Amortization
Year 1	Year 2	Year 3	Year 4	Year 5	Total
$121,429	$121,429	$121,429	$121,429	$121,429	$607,143
10 years
Amortization
Year 1	Year 2	Year 3	Year 4	Year 5	Total
$85,000	$85,000	$85,000	$85,000	$85,000	$425,000

Figure 1. Total BIM results by year.