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Original Research Article

Inappropriate dosing of direct oral anticoagulants: findings from a clinical vignette study and physician survey

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Article: 2267327 | Received 08 Jun 2023, Accepted 03 Oct 2023, Published online: 29 Oct 2023

Figures & data

Figure 1. Patient factors for (a) apixaban (all prescribers), (b) apixaban (GP/specialist subgroups), and (c) rivaroxaban (all prescribers), inappropriate underdoses from the clinical vignette survey.

Figure 1. Patient factors for (a) apixaban (all prescribers), (b) apixaban (GP/specialist subgroups), and (c) rivaroxaban (all prescribers), inappropriate underdoses from the clinical vignette survey.

Figure 2. Self-reported (a) Understanding of DOAC guidelines and approach, (b) Perception of DOAC dosing confidence, and (c) Perception of DOAC underdose risk, all respondents (N=335; 150 GPs, 185 specialists), derived from the physician survey.

Figure 2. Self-reported (a) Understanding of DOAC guidelines and approach, (b) Perception of DOAC dosing confidence, and (c) Perception of DOAC underdose risk, all respondents (N=335; 150 GPs, 185 specialists), derived from the physician survey.

Table 1. Demographics, characteristics, and comparison of prescribers who selected no and ≥1 inappropriate underdose(s)* (N = 336; 150 GPs, 186 specialists).

Table 2. Comparison of key prescriber demographics or characteristics by no or ≥1 inappropriate underdose decisions (t-test).

Table 3. Key characteristics of survey participants by specialty×.

Figure 3. Schematic of main characteristics* associated with inappropriate underdosing of DOACs.

* Patient characteristics based on clinical vignette analysis of most common prescribing choices (apixaban and rivaroxaban); prescriber characteristics based on survey analysis.
Figure 3. Schematic of main characteristics* associated with inappropriate underdosing of DOACs.
Supplemental material

Supplemental Material

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