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Original Research Article

Observational study on the therapeutic management and economic burden of adult patients with moderate to severe plaque psoriasis in France – the POP study

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Article: 2270293 | Received 11 May 2023, Accepted 09 Oct 2023, Published online: 01 Nov 2023

Figures & data

Table 1. Participant’s characteristics at index date×.

Table 2. Proportion of patients with moderate to severe psoriasis who used at least once systemic treatments or phototherapy, by study year (n = 1,848 patients).

Figure 1. Study population selection process.

EGB: The Echantillon Généraliste des Bénéficiaires is a sample (1/97th of the beneficiaries) of the National Health Data System (SNDS, Système National des Données de Santé) of the National Health Insurance.
Figure 1. Study population selection process.

Figure 2. Systemic treatments and phototherapy sequences in patients with moderate to severe psoriasis after their index date (n = 1,848 patients).

The x-axis represents the time since the index date (reimbursement of the first systemic treatment, phototherapy, or hospital stay for psoriasis), in months (the index date is at x = 0). The 1,848 patients are stacked on the y-axis. Horizontal lines represent the treatment course of patients. Each color represents a treatment. Dark blue is time spent at the hospital, white represents absence of treatment, gray is the end of follow-up, and black is death. The large number of patients and the blurred display prevent seeing rapid alternating therapies.
Figure 2. Systemic treatments and phototherapy sequences in patients with moderate to severe psoriasis after their index date (n = 1,848 patients).

Figure 3. Systemic treatments and phototherapy sequences in patients treated with biotherapies before and after the index date (n = 351 patients).

The alternating treatment cessions sequences are visible on as well as association of treatments, for instance methotrexate (purple) used in association with adalimumab (light blue).
Figure 3. Systemic treatments and phototherapy sequences in patients treated with biotherapies before and after the index date (n = 351 patients).

Figure 4. Estimated mean healthcare costs in patients with moderate to severe psoriasis (all diseases and injuries) and in control patients, computed with the GEE model.

C:Control patients. P: patients with moderate to severe psoriasis. Hospital costs: hospital stay, home hospitalization, outpatient visit. Other costs: doctors’ visits (GP and specialists in the community setting), other healthcare professionals’ visits (nurses, physiotherapists, etc.), medical procedures, biological tests, medical devices, transportation, other costs (spa treatment, dialysis, etc.).
Figure 4. Estimated mean healthcare costs in patients with moderate to severe psoriasis (all diseases and injuries) and in control patients, computed with the GEE model.
Supplemental material

Supplemental Material

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Data availability statement

The data supporting the study findings are part of the National health data system (SNDS, Système national des Données de Santé) and are available from the HDH (Health Data Hub https://www.health-data-hub.fr/). Restrictions apply to the availability of these data, which were used with a special permission granted by the HDH (File No. 3358814) on 20 January 2021.