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European Clinical Respiratory Journal Volume 9, 2022 - Issue 1
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Review Article

Eosinophilic airway diseases: basic science, clinical manifestations and future challenges

Christer Jansona Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, SwedenCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5093-6980View further author information
ORCID Icon,
Leif Bjermerb Department of Respiratory Medicine and Allergology, Skane University Hospital, Lund, SwedenView further author information
,
Lauri Lehtimäkic Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland;d Allergy Centre, Tampere University Hospital, Tampere, FinlandORCID Iconhttps://orcid.org/0000-0003-1586-4998View further author information
ORCID Icon,
Hannu Kankaanrantac Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland;e Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden;f Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, FinlandORCID Iconhttps://orcid.org/0000-0001-5258-0906View further author information
ORCID Icon,
Jussi Karjalainenc Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland;d Allergy Centre, Tampere University Hospital, Tampere, FinlandView further author information
,
Alan Altrajag Department of Pulmonology, University of Tartu and Lung Clinic, Tartu University Hospital, Tartu, EstoniaView further author information
,
Valentyna Yasinskah Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Huddinge, SwedenView further author information
,
Bernt Aarlii Department of Clinical Science, University of Bergen and Department of Thoracic Medicine, Haukeland University Hospital, Bergen, NorwayView further author information
,
Madeleine Rådingere Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, SwedenView further author information
,
Johan Hellgrenj Department of Otorhinolaryngology, University of Gothenburg, Gothenburg, SwedenView further author information
,
Magnus Lofdahlk Respiratory Medical Affairs, GSK, Solna, SwedenView further author information
,
Peter H Howarthl Respiratory Medical Franchise, GSK, Brentford, Middlesex, UKView further author information
&
Celeste Porsbjergm Department of Respiratory Medicine, Bispebjerg Hospital and Copenhagen University, Copenhagen, DenmarkView further author information
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Article: 2040707 | Received 08 Nov 2021, Accepted 07 Feb 2022, Published online: 02 Mar 2022

Figures & data

Figure 1. Eosinophils are equipped with an array of cell surface receptors and intracellular mediators that facilitate interactions with their microenvironment.

Figure 1. ER, endoplasmic reticulum; IL, interleukin; ILC2s, type 2 innate lymphoid cells; MHC, major histocompatibility complex; PAR, protease-activated receptor; PIRB, paired immunoglobulin-like receptor B; PPAR, peroxisome proliferator-activated receptor; PRR, pattern-recognition receptor; SIGLEC, sialic acid binding immunoglobulin-like lectin; TH2, T helper type 2.

Figure 1. Eosinophils are equipped with an array of cell surface receptors and intracellular mediators that facilitate interactions with their microenvironment.Figure 1. ER, endoplasmic reticulum; IL, interleukin; ILC2s, type 2 innate lymphoid cells; MHC, major histocompatibility complex; PAR, protease-activated receptor; PIRB, paired immunoglobulin-like receptor B; PPAR, peroxisome proliferator-activated receptor; PRR, pattern-recognition receptor; SIGLEC, sialic acid binding immunoglobulin-like lectin; TH2, T helper type 2.

Figure 2. The roles of eosinophils in health and disease.

Figure 2. The roles of eosinophils in health and disease.

Figure 3. The longitudinal NORDSTAR dataset for the study of asthma across Nordic countries. DSAR, Danish Severe Asthma Register; NORDSTAR, NORdic Dataset for aSThmA Research.

Figure 3. The longitudinal NORDSTAR dataset for the study of asthma across Nordic countries. DSAR, Danish Severe Asthma Register; NORDSTAR, NORdic Dataset for aSThmA Research.

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