The relationship of gastroesophageal reflux disease and asthma control

Figures & data

Table 1. Demographics and Baseline Characterestics of Study Population.

	Number of Patients	Percentage of Total Study Population
Age in Years
4–17	117	41%
18–64	139	49%
65+	30	10%
Gender
Female	109	38%
Male	177	62%
Ethnicity
African American	133	47%
Hispanics	8	3%
Caucasian	104	36%
Other	41	14%
GERD Status
Positive	127	44%
Negative	159	56%
Spirometry
FEV1% ≥ 80%	156	55%
FEV1% < 80%	130	45%
Fractional Exhaled Nitric Oxide (n = 229)
Low FeNO	157	69%
High FeNO	72	31%

FEV1% = Forced Expiratory Volume in the first second of expiration.

FeNO = Fractional Exhaled Nitric Oxide.

Demographics and baseline characteristics of the n = 286 study participants with the exception of FeNO (n = 229). Low FeNO encompasses adults with FeNO ≤ 25 ppb and children younger than 12-years-old with FeNO ≤ 20, and High FeNO encompasses adults with FeNO > 25, children younger than 12-years-old with FeNO > 20.

Table 2. Adjusted Effect of GERD Status on ACT Score using Linear regression Model.

Variable	Estimate	95% CI	P value
Intercept	18.6	(17.2, 20.0)	<.001
GERD Status
No GERD		Reference
GERD	−3.6	(−4.6, −2.6)	<.001

GERD = Gastro-esophageal reflux disease.

Multiple variable linear regression model looking at the adjusted effect of GERD status on ACT score compared to a base reference value. The effect of GERD on ACT scores, FEV1%, and FeNO were compared.

Figure 1. Mean ACT scores (± SD) of asthmatics patients with GERD and without GERD diagnosis. Line over bar indicates comparison groups and statistical significance stated as P-values.

Figure 2. Mean ACT scores (± SD) for asthmatics with and without a GERD diagnosis as grouped by FEV1% < 80% and FEV1% ≥ 80%. Line over bar indicates comparison groups and statistical significance stated as P-values.

Figure 3. Mean ACT scores (± SD) for asthmatics with and without a GERD diagnosis as grouped by low FeNO and high FeNO. Line over bar indicates comparison groups and statistical significance stated as P-values.

Data availability statement

All data relevant to the findings of the study are included within the article or its supplementary materials. The raw anonymized data extracted from individual patient records can be made available if requested.