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CNS Oncology Volume 13, 2024 - Issue 1
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Case Report

BRAF V600E-mutant colorectal cancer with CNS metastases treated successfully with encorafenib, binimetinib and cetuximab

Toru Imaia Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo,  104-0045, Japan
,
Hirokazu Shojia Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo,  104-0045, JapanCorrespondence[email protected]
,
Hidekazu Hiranoa Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo,  104-0045, Japan
,
Kunihito Matsugumaa Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo,  104-0045, Japan
,
Takahito Awatsua Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo,  104-0045, Japan
,
Toshiharu Hirosea Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo,  104-0045, Japan
,
Natsuko Okitaa Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo,  104-0045, Japan
,
Atsuo Takashimaa Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo,  104-0045, Japan
&
Ken Katoa Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo,  104-0045, Japan
 show all
Article: 2347824 | Received 02 Oct 2023, Accepted 23 Apr 2024, Published online: 22 May 2024

Figures & data

Figure 1. Contrast-enhanced magnetic resonance images of the head. (A) Brain metastasis in the right occipital lobe and leptomeningeal disease along the cerebellar sulci. (B) Disappearance of brain metastasis and leptomeningeal disease.

The red arrows indicate the metastatic areas.

Figure 1. Contrast-enhanced magnetic resonance images of the head. (A) Brain metastasis in the right occipital lobe and leptomeningeal disease along the cerebellar sulci. (B) Disappearance of brain metastasis and leptomeningeal disease.The red arrows indicate the metastatic areas.

Figure 2. Magnetic resonance images showing multiple brain infarctions (Trousseau's syndrome).

The red arrows indicate the metastatic areas.

Figure 2. Magnetic resonance images showing multiple brain infarctions (Trousseau's syndrome).The red arrows indicate the metastatic areas.

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