The association between thyroid function and nutritional status in patients with end-stage renal disease on hemodialysis

Figures & data

Table 1. Anthropometric and biochemical characteristics of the patients (N = 84)

	Mean	Standard deviation	Range
Weight (kg)	75.3	15.83	(48–142)
Height (cm)	170.19	8.43	(155–186)
BMI (kg/m^2)	25.94	5.27	(17–42)
MAC (cm)	28.43	4.63	(19–44)
SGA score	13.73	4.4	(7–25)
CCI	5.54	2.137	(2–11)
Free T3 (pg/mL)	2.55	0.52	(1.18–3.64)
Free T4 (ng/dl)	1.08	0.206	(0.65–1.62)
TSH (uIU/ml)	2.99	2.93	(0.01–17.1)
Hemoglobin (g/dl)	9.7	1.42	(6.9–13.7)
Creatinine (mg/dl)	8.4	1.9	(3.7–13.3)
Serum iron (mg/l)	0.7	0.36	(0.23–2.78)
TIBC (mg/l)	2.35	0.41	(1.6–3.6)
Albumin (g/dl)	3.55	0.52	(2.36–4.9)
KT/V	1.2	0.23	(0.55–1.67)
Urea (mg/dl)	172.42	53.12	(80–300)
Cholesterol (mg/dl)	178.29	29.04	(134–256)
CRP (mg/l)	10.14	8.9	(0.4–36.5)

BMI: Body mass index MAC: Mid arm circumference SGA score: Subjective global assessment score. CCI: Charlson comorbidity index Free T3: Free Triiodothyronine Free T4: Free Thyroxine CRP: C reactive protein TSH: Thyroid Stimulating Hormone TIBC: Total iron-binding capacity

Figure 1. Correlation between free T3 and SGA score

Table 2. Correlation between SGA and other variables (N = 84)

Variable	SGA
	R	P
Free T3 (pg/mL)	−0.51	0.001
Free T4 (ng/dl)	−0.01	0.9
TSH (uIU/ml)	+0.047	0.6
Age (years)	+0.09	0.3
Weight (kg)	−0.48	0.001
BMI (kg/m^2)	−0.58	0.001
MAC (cm)	−0.58	0.001
Hb (g/dl)	−0.24	0.02
Creatinine (mg/dl)	−021	0.05
Serum iron (mg/l)	−0.07	0.5
TIBC (mg/l)	−0.1	0.3
Serum albumin (g/dl)	−0.54	0.001
KT/V	+0.05	0.6
Urea (mg/dl)	−0.03	0.7
Cholesterol (mg/dl)	−0.53	0.001
Duration of dialysis (years)	+0.36	0.001
CRP (mg/l)	+0.67	0.001
CCI	+0.63	0.001

BMI: Body mass index MAC: Mid arm circumference Free T3: Free Triiodothyronine CRP: C reactive protein TIBC: Total iron-binding capacity Hb: Hemoglobin CCI: Charlson comorbidity index Free T4: Free Thyroxine TSH: Thyroid Stimulating Hormone

Table 3. Univariate regression analysis for SGA (N = 84)

Variable	Β	95%Confidence interval	P value
Free T3 (pg/mL)	−4.03	−5.65 to −2.41	0.001
Age (years)	0.076	−0.009 to 0.16	0.07
Weight (kg)	−.07	−0.13 to −0.013	0.017
BMI (kg/m^2)	−0.2	−0.38 to −0.03	0.023
MAC (cm)	−0.32	−0.5 to −0.12	0.002
Hb (g/dl)	−0.8	−1.4 to −0.18	0.012
Creatinine (mg/dl)	−0.5	−0.99 to −0.011	0.045
Albumin (g/dl)	−3.43	−4.9 to −1.9	0.001
Cholesterol (mg/dl)	−0.037	−0.069 to −0.005	0.023
Duration of dialysis	0.053	0.016 to 0.091	0.006
CRP (mg/l)	0.35	0.28 to 0.43	0.001
MIS	0.89	0.82 to 0.96	0.001
CCI	1.52	1.23 to 1.8	0.001

BMI: Body mass index MAC: Mid arm circumference Free T3: Free Triiodothyronine CRP: C reactive protein Hb: Hemoglobin MIS: Malnutrition Inflammation Score CCI: Charlson comorbidity index

Table 4. Multivariate regression analysis for SGA (N = 84)

Variable	Β	95%Confidence interval	P value
Constant	26.11
Free T3 (pg/mL)	−1.36	−2.5 to −0.2	0.02
Weight (kg)	0.01	−0.05 to 0.07	0.7
BMI (kg/m^2)	−0.28	−0.5 to 0.05	0.01
MAC (cm)	0.002	−0.18 to 0.18	0.9
Hb (g/dl)	−0.06	−0.42 to 0.29	0.7
Albumin (g/dl)	−1.26	2.3 to 0.22	0.01
Cholesterol (mg/dl)	−0.036	−0.055 to −0.017	0.001
Duration of dialysis (years)	0.006	−0.017 to 0.027	0.6
CRP (mg/l)	0.11	0.036 to 0.19	0.004
CCI	0.4	0.1 to 0.7	0.009

BMI: Body mass index MAC: Mid arm circumference Free T3: Free Triiodothyronine CRP: C reactive protein Hb: Hemoglobin CCI: Charlson comorbidity index

Table 5. Correlation between free T3 and other variables (N = 84)

Variable	Free T3
	R	P
SGA Score	−0.49	0.001
Age (years)	−0.25	0.02
Duration of dialysis (years)	+0.06	0.6
Weight (kg)	+0.07	0.5
BMI (kg/m^2)	+0.13	0.2
MAC (cm)	+0.16	0.14
CCI	−0.48	0.001
KT/V	+0.25	0.02
Hb (g/dl)	+0.08	0.46
TIBC (mg/l)	−0.05	0.6
Albumin (g/dl)	+0.47	0.001
Urea (mg/dl)	+0.16	0.15
Cholesterol (mg/dl)	−.01	0.35
CRP (mg/l)	−0.46	0.001

BMI: Body mass index MAC: Mid arm circumference Free T3: Free Triiodothyronine CRP: C reactive protein TIBC: Total iron-binding capacity Hb: Hemoglobin CCI: Charlson comorbidity index SGA score: Subjective global assessment score.