Effect of a tadalafil 5-mg single daily dose on lifelong premature ejaculation: A single-blinded placebo-controlled study

Figures & data

Figure 1. Flow chart of the patients included in the study.

Table 1. Baseline characteristics of tadalafil 5-mg and placebo patients

	Tadalafil 5 mg (N = 27)	Placebo (N = 28)	P*
Age, years, mean (SD)	30.4 (3.8)	30.4 (3.8)	0.941
Smoker, n (%)	14 (51.9)	14 (50)	0.553
Duration of PE, years, mean (SD)	5.8 (2)	5.9 (2.4)	0.109
Number of children, mean (SD)	2.1 (1)	1.9 (1.1)	0.705
Frequency of intercourse/week, mean (SD)	2.6 (0.9)	2.4 (0.9)	0.653
Baseline IELT, s, mean (SD)	45.7 (9.1)	43.2 (12.1)	0.127
Baseline PEDT score, mean (SD)	14.7 (2.4)	14.2 (3.2)	0.128

*Independent t-test.

Table 2. Comparisons of the mean (SD) IELTs and total PEDT scores between the tadalafil 5-mg and placebo groups after 1 and 3 months

Variable, mean (SD)	Tadalafil 5 mg (N = 27)	Placebo (N = 28)	P*
IELT after 1 month, s	50.6 (9.3)	48.2 (10)	0.772
IELT after 3 months, s	52.3 (7.6)	47.7 (9.6)	0.153
Improvement in IELT after 1 month, s	4.8 (4.7)	5 (4.9)	0.657
Improvement in IELT after 3 months, s	6.6 (7)	4.5 (9)	0.610
PEDT score after 1 month	12.6 (2.8)	12.2 (2.9)	0.852
PEDT score after 3 months	11.2 (3.2)	10.7 (2.8)	0.358
PEDT improvement after 1 month	2.1 (1.9)	2 (1.5)	0.713
PEDT improvement after 3 months	3.5 (2.5)	3.3 (2.2)	0.812

*Independent t-test.

Table 3. PEDT scores at baseline

No.	Question	Tadalafil 5 mg (N = 27), mean (SD)	Placebo (N = 28), mean (SD)	P
1	How difficult is it for you to delay ejaculation?	2.9 (1)	2.6 (1.2)	0.382
2	Do you ejaculate before you want to?	3.2 (0.7)	3 (1)	0.169
3	Do you ejaculate with very little stimulation?	2.4 (1.1)	2.2 (1.3)	0.279
4	Do you feel frustrated because of ejaculating before you want to?	2.7 (1)	3 (1.1)	0.866
5	How concerned are you that your time to ejaculation leaves your partner unfulfilled?	2.9 (1.1)	2.7 (1.2)	0.177
Total score		14.7 (2.4)	14.2 (3.2)	0.128

Table 4. PEDT scores after 1 month

No.	Question	Tadalafil 5 mg (N = 27), mean (SD)	Placebo (N = 28), mean (SD)	P
1	How difficult is it for you to delay ejaculation?	2.9 (0.8)	2.7 (1)	0.1
2	Do you ejaculate before you want to?	2.5 (0.9)	2.6 (0.8)	0.495
3	Do you ejaculate with very little stimulation?	2.6 (0.9)	2.5 (0.9)	0.993
4	Do you feel frustrated because of ejaculating before you want to?	2.4 (0.7)	2.3 (0.7)	0.553
5	How concerned are you that your time to ejaculation leaves your partner unfulfilled?	2.3 (0.7)	2.1 (0.9)	0.731
Total score		12.6 (2.8)	12.2 (2.9)	0.852

Table 5. PEDT scores after 3 months

No.	Question	Tadalafil 5 mg (N = 27)	Placebo (N = 28)	P
1	How difficult is it for you to delay ejaculation?	2.7 (1.1)	2.4 (1)	0.326
2	Do you ejaculate before you want to?	2.3 (0.9)	2.1 (0.8)	0.181
3	Do you ejaculate with very little stimulation?	2.2 (1.1)	2 (1)	0.264
4	Do you feel frustrated because of ejaculating before you want to?	2.1 (0.6)	2.2 (0.9)	0.055
5	How concerned are you that your time to ejaculation leaves your partner unfulfilled?	1.9 (0.6)	2 (0.8)	0.570
Total score		11.2 (3.2)	10.7 (2.8)	0.358

Table 6. Drug-related side-effects

Side-effect, n (%)	Tadalafil 5 mg (N = 27)	Placebo (N = 28)	P
Headache	5 (18.5)	0	0.005
Back pain and myalgia	2 (7.4)	0
Flushing	3 (11.1)	0
Total	10 (37)	0

Data availability statement

The data confidentiality was ensured. Data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.