The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica

Figures & data

Figure 1. Chemical structure of Nigronapthaphenyl.

Table 1. ¹³C NMR data of Nigronapthaphenyl.

C#	13C δ (ppm)	C#	13C δ (ppm)	C#	13C δ (ppm)	C#	13C δ (ppm)
1	129.1	6	138.7	11	131.2	16	130.4
2	128.2	7	98.7	12	130.2	17	196.4
3	126.5	8	154.4	13	133.4	18	58.3
4	129.3	9	152.2	14	130.3	19	61.3
5	133.4	10	132.3	15	131.3	20	58.2

Table 2. ¹H NMR data of Nigronapthaphenyl.

C#	1H δ (ppm)	C#	1H δ (ppm)	C#	1H δ (ppm)	C#	1H δ (ppm)
1	8.00	6	-	11	7.87	16	-
2	8.15	7	6.69	12	7.62	17	-
3	-	8	-	13	7.53	18	4.17
4	8.63	9	-	14	7.52	19	3.84
5	-	10	-	15	7.88	20	3.91

Table 3. HSQC and HMBC correlations of Nigronapthaphenyl.

C#	HSQC (ppm)	HMBC
1	8.00	2,3
2		1,3,10
3		-
4	8.63	3,5
5		-
6		-
7	6.69	6,8,9
8		-
9		-
10		-
11	7.88	12,16
12		11,13
13		12,14,15
14	7.53	13,15
15		14,16
16		-
17		-
18	4.18	6
19	3.98	8
20	4.10	9

Table 4. MIC values obtained for Nigronapthaphenyl and for positive controls.

	Minimum Inhibitory Concentration Values (MIC) – µg/mL
Compound Name	B. subtilis	B. subtilis TISTR 088	B. cereus TISTR 688	S. aureus	E. coli	MRSA	C. albicans	P. aeruginosa	C. gloeosporioides	A. niger
Nigronapthaphenyl	4	4	2	4	2	2	2	2	4	8
Polymixin B	4	1	1	-	1	-	-	1	-	-
Amphotericin	-	-	-	-	-	-	1	-	1	1
Rifamycin	-	-	-	1	-	1	-	-	-	1