Invasive infections due to Magnusiomyces capitatus: case report and review of its prevalence in China

Figures & data

Table 1. Summary of the clinical and microbiological profile of the seven Chinese cases

Parameter	Case 1	Case 2	Case 3	Case 4	Case 5	This case
Year	2011	2015	2018	2013	2018	2018
Age/gender	53/female	25/male	14/female	64/Male	92/male	74/male
Underlying disease	Lymphoma	Leukaemia	Aplastic anaemia	COPD, coronary heart disease	Diabetes, aged	Right upper lobe lobectomy
Chemotherapy	Yes	Yes	Yes	no	No	No
Clinical symptoms	Fever	Fever	Fever	cough	Cough, fever	Cough
Culture	Positive (blood)	Positive (blood)	Positive (blood)	positive (sputum, both KOH and culture)	Positive (sputum, both KOH and culture)	Positive (sputum, both KOH and culture)
Diagnosis	Fungemia	Fungemia	Fungemia	pneumonia	Pneumonia	Bronchiectasis and pneumonia
Pathogen identification	Sequencing, morphology	Morphology	Sequencing, morphology	morphology, biochemical methods*	Sequencing, morphology	Sequencing, morphology
G-test/GM	N	G/GM positive	GM positive	N	N	N
Therapy in vivo	AmB + 5-FC	Am B + Vor	AmB + Cas	Flu	Flu + 5-FC	Flu
outcome	Good	Good	Good	good	Good	good
reference	8	9	10	11	12

* ATB Expression bacteria identification Instrument (French bio-Merieux).

AmB: amphotericin B; 5-FC: 5-fluorocytosine; Vor: voriconazole; Cas: caspofungin; Flu: fluconazole; N: no test.

Table 2. Results of in vitro antifungal susceptibility, clinical therapy, and outcome for the seven Chinese cases

Case	Method	In vitro antifungal susceptibility									Therapy in vivo	Response
		AmB	5-FC	FLU	ITR	VOR	POS	CAS	MICA	ANI
1	Unknown	S	S	S	S	S	-	-	-	-	Amphotericin B + 5-fluorocytosine	Good
2	Unknown	S	S	I	I	S	-	-	-	-	Amphotericin B + voriconazole	Good
3	Unknown	S	S	-	-	S	-	-	-	-	Amphotericin B + caspofungin	Good
4	Agar diffusion	S	S	I	I	-	-	-	-	-	Amphotericin B + voriconazole	Good
5	ATB fungus	S	S	S	S	S	-	-	-	-	Fluconazole	Good
6	Agar diffusion	-	S	S	S	S	-	-	-	-	Fluconazole + 5-fluorocytosine	Good
This	M27-A (µg/mL)	2 (S)	0.125 (S)	4 (S)	0.5 (S)	0.5 (S)	2 (*)	8 (*)	1 (*)	2 (*)	Fluconazole	Good

*There is no interpretive breakpoint.

AmB: amphotericin B; 5-FC: 5-fluorocytosine; FLU: fluconazole; ITR: itraconazole; VOR: voriconazole; POS: posaconazole; CAS: caspofungin; MICA: micafungin; ANI: anidulafungin; S: susceptible; -: not test; I: intermediate.