Figures & data
Figure 1. Model of Set2-dependent gene silencing. At the transcriptional initiation step, Set2 is recruited to chromatin independently of Pol2 CTD, and methylates H3K36 up to dimethylation. At the elongation step, Pol2 CTD S2 and S5 are phosphorylated, and Set2 interacts with Pol2 CTD to co-transcriptionally methylate H3K36 up to trimethylation along the gene body. This leads to post-transcriptional gene silencing in heterochromatin and contributes to transcriptional gene silencing in the subtelomeric region.
