Figures & data
Figure 1. Model proposing the pleiotropic function of Foxa3 on energy conservation, during high fat diet and aging. (A) Foxa3 mRNA levels are selectively increased in visceral fat (Vis fat) in response to high fat diet (HFD) and associated with increased lipid accumulation in the visceral depot and the induction of PPARγ mRNA. (B) Foxa3 levels are primarily elevated in subcutaneous fat depots during the aging process. Schematic representation depicting the competition between Foxa3 and CREB for their binding to regulatory elements at the PGC1α promoter, resulting in the modulation of PGC1α mRNA levels. EE, energy expenditure.
