Figures & data
Figure 1. Intricate interplay between circadian clock, brown fat and body temperature homeostatic regulation. Temperature is a universal clock resetting signal. The clock, through central clock-driven neuronal innervation to brown fat or the brown fat intrinsic clock regulations, feeds into body temperature homeostatic control.
Figure 2. Molecular clock control of the TGFβ signaling cascade modulates brown adipogenesis. The opposing transcriptional regulators of the molecular clock circuit, Bmal1 and Rev-erbα, exerts positive and negative transcriptional regulations of key components of the TGFβ signaling pathway, through their specific E-box and RORE elements, respectively. This regulation of TGFβ pathway, a key inhibitory mechanism of brown adipocyte development, leads to suppression and promotion of mesenchymal commitment to the brown lineage and its subsequent mature differentiation to mature adipocyte by Bmal1 and Rev-erbα, respectively.
