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Adipocyte Volume 7, 2018 - Issue 2
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Commentary

Endoplasmic reticulum stress epigenetics is related to adiposity, dyslipidemia, and insulin resistance

Omar Ramos-LopezDepartment of Nutrition, Food Science and Physiology, and Center for Nutrition Research, University of Navarra, Pamplona, SpainView further author information
,
Jose I. Riezu-BojDepartment of Nutrition, Food Science and Physiology, and Center for Nutrition Research, University of Navarra, Pamplona, Spain;Navarra Institute for Health Research (IdiSNA), Pamplona, SpainView further author information
,
Fermin I. MilagroDepartment of Nutrition, Food Science and Physiology, and Center for Nutrition Research, University of Navarra, Pamplona, Spain;CIBERobn, Fisiopatología de la Obesidad y la Nutrición; Carlos III Health Institute, Madrid, SpainORCID Iconhttp://orcid.org/0000-0002-3228-9916View further author information
ORCID Icon,
Maria J. Moreno-AliagaDepartment of Nutrition, Food Science and Physiology, and Center for Nutrition Research, University of Navarra, Pamplona, Spain;Navarra Institute for Health Research (IdiSNA), Pamplona, Spain;CIBERobn, Fisiopatología de la Obesidad y la Nutrición; Carlos III Health Institute, Madrid, SpainView further author information
,
J. Alfredo MartinezDepartment of Nutrition, Food Science and Physiology, and Center for Nutrition Research, University of Navarra, Pamplona, Spain;Navarra Institute for Health Research (IdiSNA), Pamplona, Spain;CIBERobn, Fisiopatología de la Obesidad y la Nutrición; Carlos III Health Institute, Madrid, Spain;Madrid Institute of Advanced Studies (IMDEA Food), Madrid, SpainCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-5218-6941View further author information
ORCID Icon & project MENA
Pages 137-142 | Received 10 Jan 2018, Accepted 27 Feb 2018, Published online: 23 Mar 2018

Figures & data

Figure 1. Correlations between methylation levels (beta values) at ER stress genes and WC after adjustments for age and sex. (A) cg08188400, MAP2K7 (B) cg20541779, CASP12 (C) cg24776411, EIF2AK1 (D) cg14190817, HSPA5 (E) cg21376454, ERN1 (F) cg06666486, EIF2AK1 (G) cg03211481, DNAJC1 (H) cg18357645, OS9 (I) cg05801879, MBTPS1 (J) cg20964082, ERO1LB (K) cg17300868, NFE2L2 (L) cg03384128, EIF2AK4 (M) cg02712587, EIF2AK4 (N) cg04972384, SELS (O) cg02240686, EIF2AK2.

Figure 1. Correlations between methylation levels (beta values) at ER stress genes and WC after adjustments for age and sex. (A) cg08188400, MAP2K7 (B) cg20541779, CASP12 (C) cg24776411, EIF2AK1 (D) cg14190817, HSPA5 (E) cg21376454, ERN1 (F) cg06666486, EIF2AK1 (G) cg03211481, DNAJC1 (H) cg18357645, OS9 (I) cg05801879, MBTPS1 (J) cg20964082, ERO1LB (K) cg17300868, NFE2L2 (L) cg03384128, EIF2AK4 (M) cg02712587, EIF2AK4 (N) cg04972384, SELS (O) cg02240686, EIF2AK2.

Figure 2. Tenth, 25th, 50th, 75th, and 90th percentiles of methylation levels (beta values) at ER regulatory genes by categories of insulin, HOMA-IR and triglycerides after adjustments for age and sex in subjects with excessive weight. (A) cg17300868, NFE2L2 (B) cg20964082, ERO1LB (C) cg17300868, NFE2L2 (D) cg20964082, ERO1LB (E) cg05801879, MBTPS1 (F) cg03384128, EIF2AK4. a p < 0.0001. b p < 0.05.

Figure 2. Tenth, 25th, 50th, 75th, and 90th percentiles of methylation levels (beta values) at ER regulatory genes by categories of insulin, HOMA-IR and triglycerides after adjustments for age and sex in subjects with excessive weight. (A) cg17300868, NFE2L2 (B) cg20964082, ERO1LB (C) cg17300868, NFE2L2 (D) cg20964082, ERO1LB (E) cg05801879, MBTPS1 (F) cg03384128, EIF2AK4. a p < 0.0001. b p < 0.05.

Figure 3. Epigenetic regulation of endoplasmic reticulum stress in obesity and associated metabolic diseases. Obesity induces a chronic activation of the unfolded protein response and consequently ER stress. Differentially methylated ER regulatory genes play a pivotal role in obesity-induced ER stress, leading to the development of metabolic disturbances. Hypomethylated (red color); hypermethyated (blue color).

Figure 3. Epigenetic regulation of endoplasmic reticulum stress in obesity and associated metabolic diseases. Obesity induces a chronic activation of the unfolded protein response and consequently ER stress. Differentially methylated ER regulatory genes play a pivotal role in obesity-induced ER stress, leading to the development of metabolic disturbances. Hypomethylated (red color); hypermethyated (blue color).

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