Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescents

Figures & data

Table 1. Characteristics of study participants in obese and overweight adolescent boys at baseline.

	OverWeight (n = 30)	Obese (n = 32)	P
Age(year)	13.89 ± 0.914	13.90 ± .918	0.67
BMI(Kg/m^2)	23.5731 ± 1.62	29.1592 ± 2.94498	0.00
FM%	24.1214 ± 5.66	31.1673 ± 5.02230	0.00
SM%	36.4715 ± 2.39	33.6735 ± 2.09352	0.00
PA(MET-minute per week)	1744 ± 2355.46	1894 ± 2598.27318	0.31
Calorie(Kcal)	2168 ± 772.35	2192 ± 1134.02343	0.92
Protein intake(gr/day)	166.12 ± 280.18	88.29 ± 48.95	0.16
Carbohydrate intake(gr/day)	220.41 ± 86.16	248.49 ± 105.12	0.26
Fat intake(gr/day)	177.33 ± 89.89	170.36 ± 75.43	0.74
FTO	3.1764 ± 10.63104	1.7829 ± 2.03810	0.5
IRX3	11.2229 ± 4.57277	2.8662 ± 3.92054	0.38

Table 2. The association of changes of macronutrients’ intake with changes in FTO and IRX3 gene expression over a period of 18 weeks.

	FTO		IRX3
	Beta	P	Beta	P
Protein intake(gr/day)	0.65	0.000	−0.07	0.57
Carbohydrate intake(gr/day)	0.97	0.001	−1.07	0.01
Fat intake(gr/day)	−0.05	0.65	−1.16	0.26

Adjusted for age, Kcal, BMI, FM, SM, and PA.

Table 3. The association of macronutrients’ intake with FTO and IRX3 gene expression based on different FTO genotypes.

	AA/AG				GG
	FTO		IRX3		FTO		IRX3
	Beta	P	Beta	P	Beta	P	Beta	P
Protein intake	0.66	0.000	−0.09	0.57	0.03	0.94	−0.01	0.98
Carbohydrate intake	0.49	0.21	−0.74	0.04	1.56	0.04	−0.7	0.43
Fat intake	−0.01	0.99	−0.19	0.49	−0.57	0.07	−0.67	0.29

Adjusted for age, Kcal, BMI, Fat mass, Skeletal Muscle, and Physical Activity.