Differences in fatty acid profiles and desaturation indices of abdominal subcutaneous adipose tissue between pregnant women with and without PCOS

Figures & data

Table 1. General characteristics of study participants (PCOS: polycystic ovary syndrome and non-PCOS) and fatty acid profiles in experimental groups (Means ± sd)

	non-PCOS (n = 32)	PCOS (n = 13)	P-Value
Age (year)	31.5 ± 5.42	31.4 ± 3.57	NS
BMI (kgm^−2) before pregnancy	26.5 ± 4.93	26 ± 5.92	NS
BMI (kgm^−2) at delivery day	31 ± 5.33	30.1 ± 5.35	NS
Fatty Acids (% of total fatty acids)
C 12:0	0.29 ± 0.16	0.26 ± 0.12	NS
C 14:0	1.67 ± 0.46	1.92 ± 0.47	NS
C 15:0	0.23 ± 0.1	0.30 ± 0.16	NS
C 16:0	22.2 ± 2.59	21.73 ± 1.85	NS
C 17:0	0.30 ± 0.15	0.41 ± 0.17	0.040
C 18:0	3.89 ± 1.15	3.29 ± 0.89	NS
C 14:1	0.19 ± 0.11	0.22 ± 0.12	NS
C 15:1	0.09 ± 0.12	0.04 ± 0.05	NS
C 16:1	3.64 ± 0.78	4.34 ± 1.37	NS
C 18:1t6	0.26 ± 0.14	0.30 ± 0.15	NS
C 18:1t9	0.24 ± 0.13	0.18 ± 0.05	0.044
C 18:1t11	0.20 ± 0.09	0.17 ± 0.04	NS
C 18:1c	40 ± 2.47	43 ± 2.07	0.0007
C 18:2c	21.3 ± 2.23	18.9 ± 2.77	0.005
C 18:2t	0.26 ± 0.2	0.11 ± 0.06	0.0005
C 18:3 n-3	0.78 ± 0.13	0.68 ± 0.12	0.016
C 20:1	0.62 ± 0.23	0.56 ± 0.10	NS
C 20:2	0.29 ± 0.18	0.34 ± 0.06	NS
C 20:4 n-6	0.30 ± 0.18	0.40 ± 0.09	0.021
C 20:5 n-3 (EPA)	0.06 ± 0.04	0.02 ± 0.03	0.003
C 22:6n3 (DHA)	0.09 ± 0.04	0.08 ± 0.04	NS
Other fatty acids	3.12 ± 1.16	2.64 ± 0.87	NS
Total Saturated fatty acids	28.6 ± 3.66	27.9 ± 2.37	NS
Total Unsaturated fatty acids	68.3 ± 3.60	69.5 ± 2.31	NS
Total MUFA	45.2 ± 2.96	48.88 ± 2.61	0.0004
Total PUFA	23 ± 2.37	20.57 ± 2.77	0.004
Total n-6 fatty acids	23.1 ± 2.29	19.80 ± 2.73	0.006
Total n-3 fatty acids	0.93 ± 0.15	0.77 ± 0.12	0.001
n-6/n-3 ratio	24.1 ± 3.50	25.97 ± 4.31	NS
Total trans fatty acids	0.96 ± 0.34	0.76 ± 0.2	0.021
Odd chain FA	0.62 ± 0.24	0.74 ± 0.23	NS

NS; Non-significant; t: trans; c: cis; EPA: eicosapentaenoic acid; DHA: docosahexaenoic acid; BMI: Body mass index; MUFA: Monounsaturated fatty acid; PUFA: Polyunsaturated fatty acid. Fatty acids in bold were significant.

Table 2. Desaturase index (monounsaturated fatty acid/saturated fatty acid) in subcutaneous adipose tissue of pregnant PCOS (Polycystic ovary syndrome) and pregnant non-PCOS women (Mean ± sd). Desaturase index in bold was significant

	non-PCOS (n = 32)	PCOS (n = 13)	P-Value
C16:1 cis/C16:0	0.17 ± 0.05	0.20 ± 0.06	0.057
C18:1 cis/C18:0	11.3 ± 3.73	14 ± 4.14	0.035

Figure 1. Trans-fatty acid differences in subcutaneous adipose tissue of pregnant non-PCOS (n = 32) versus PCOS women (n = 13) (Mean ± sd)(* total trans: p = 0.021; C18:1 t9: p = 0.044 and C18:2:P = 0.0005)

Figure 2. Saturated fatty acid (SFA), Monounsaturated fatty acid (MUFA) and Polyunsaturated fatty acid (PUFA) differences in subcutaneous adipose tissue of pregnant non-PCOS (n = 32) versus PCOS women (n = 13) (Mean ± sd) (* p < 0.01)