Extending the lifespan and efficacies of immune cells used in adoptive transfer for cancer immunotherapies–A review

Figures & data

Figure 1. Summary of the cytokines, their receptors and their effects on the immune cells.

Table 1. Summary table of the currently known mechanisms by which the four cytokines act on immune effector cells

	Currently known mechanisms by which the agent acts
Agent	DCs	NK cells	γδ T cells	CD8^+ T cells
IL-2	Unconfirmed	Telomerase activation^121 Decrease apoptosis^133	Reversal of anergy^138	Decrease apoptosis^134 Reversal of anergy^138,139
IL-7	Unconfirmed	Decrease apoptosis^133	Unconfirmed	Telomerase activation^125 Decrease apoptosis^88
IL-21	Induces Apoptosis^107,108	Telomerase activation^122	Unconfirmed	Unconfirmed
IL-15	Decrease apoptosis^136	Decrease apoptosis^130,131	Unconfirmed	Telomerase activation^123–125 Decrease apoptosis^132

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