Figures & data
Figure 1. Schematic of proposed effect of VVΔTK-IL10 on tumor cells and viral clearance. After administration, virus particles specifically infect, replicate in and lyse tumor cells. Tumor cell lysis releases both viral () and tumor (and bull;) antigens. Experimental data suggests that these are presented to T cells via different antigen presenting cells. Data indicates that macrophages (Mϕ) are responsible for presentation of viral antigens and it is this process that is disrupted by IL-10, which causes downregulation of macrophage MHC II markers, inhibiting macrophage antigen display function. As a result, virus is cleared less rapidly, resulting in increased tumor cell infection and tumor cell antigen release. Tumor antigen recognition is unaffected by IL-10, therefore, this model suggests a distinct, possibly dendritic cell (DC)-mediated presentation of tumor antigens.
