Figures & data
Figure 1. Mammary tumor-activated γδ T cells educate immunosuppressive neutrophils to advance metastasis. IL1β released into the circulation by mammary tumors activates γδ T cells to produce IL17. An unknown cell type responds to IL17 by upregulating G-CSF, causing neutrophil expansion and polarization toward an immunosuppressive phenotype. Through an iNOS-dependent mechanism, neutrophils dampen CD8+ T cell killer functions so that disseminated cancer cells are protected from attack.
