Figures & data
Figure 1. Proposed mechanism to explain how antitumor alloantibodies initiate T cell immunity. In the typical tumor microenvironment, which is highly immunosuppressive, tumor-associated DC cannot transmit a signal through their Fcγ receptors following engagement of IgG bound to tumor antigens/cells. Administration of tumor-binding IgG in combination with TNFα and CD40L enables tumor DC to internalize tumor antigens through Fcγ receptors, which transmit a danger signal. These antigens are then processed by the DC and subsequently presented to T cells, which attack both the primary tumor as well as distant metastases.
