Figure 1. Neuroblastoma Arginase II activity, leads to local microenvironment and systemic depletion of arginine concentrations. Arginine depletion suppresses T cell proliferation, NY-ESO antigen-specific T cell immunity, and anti-GD2 CAR T cell cytotoxicity. Surrounding CD14+ monocytes are also inhibited and CD34+ haematopoietic stem cell (HSC) proliferation is impaired.
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