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Review

Cytokine patterns in cancer patients: A review of the correlation between interleukin 6 and prognosis

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Article: e1093722 | Received 14 Aug 2015, Accepted 08 Sep 2015, Published online: 11 May 2016

Figures & data

Figure 1. Median survival of 1272 cancer patients with IL-6 serum levels above various chosen cut-off values in 24 dichotomized studies (26 cohorts). Both x and y parameters have been have log-transformed in the graph. Sample size was used to weigh the studies. The median survival at chosen cut-off points was inversely correlated to the minimum IL-6 serum level at this cut-off, both when sample size was used to weigh the studies (p < 0.001) and also when the cohorts were not weighted (p < 0.005). Numbers indicate series as listed in .

Figure 1. Median survival of 1272 cancer patients with IL-6 serum levels above various chosen cut-off values in 24 dichotomized studies (26 cohorts). Both x and y parameters have been have log-transformed in the graph. Sample size was used to weigh the studies. The median survival at chosen cut-off points was inversely correlated to the minimum IL-6 serum level at this cut-off, both when sample size was used to weigh the studies (p < 0.001) and also when the cohorts were not weighted (p < 0.005). Numbers indicate series as listed in Table 2.

Table 1. Summary of clinical series with cancer patients that reported the serum level of IL-6 and its potential association with survival.

Table 2. In 24 dichotomized studies (26 cohorts) comprising 1272 patients, the median survival was reported for patients in whom the IL-6 serum level was higher than the chosen cut-off value. References, primary cancer type, number of patients, cut-off for IL-6 serum level (pg/mL) and median survival are given in the table.