Figures & data
Figure 1. Reduced tumor growth and metastasis as a consequence of impaired immune suppression in CD81KO mice. In wild-type mice, primary tumors grow and recruit immune suppressor T regulatory cells (Tregs), and myeloid-derived suppressor cells (MDSCs). These suppressor cells secrete IL-10 and inhibit the antitumor T effector (Teff) response allowing tumors to grow and metastasize to the lungs (left panel). In contrast, Tregs and MDSCs still accumulate in CD81KO mice, but are impaired at suppressing Teff cells, thereby reducing tumor growth and metastasis (right panel).
