845
Views
3
CrossRef citations to date
0
Altmetric
Author's View

GITR drives TH9-mediated antitumor immunity

, &
Article: e1122862 | Received 16 Nov 2015, Accepted 16 Nov 2015, Published online: 29 Apr 2016

Figures & data

Figure 1. A schematic illustration of TH9 cell-mediated antitumor immunity induced by GITR co-stimulation. GITR triggering inhibits iTreg cell generation and promotes TH9 cell differentiation. IL-9 production triggers epithelial cells to chemoattract DCs into the tumor and enhances the cross-presentation and costimulatory capacity of the tumor-infiltrating DCs. These tumor-Ag-crosspresenting DCs then potentiate tumor-specific CD8+ CTL responses, thereby facilitating tumor regression.

Figure 1. A schematic illustration of TH9 cell-mediated antitumor immunity induced by GITR co-stimulation. GITR triggering inhibits iTreg cell generation and promotes TH9 cell differentiation. IL-9 production triggers epithelial cells to chemoattract DCs into the tumor and enhances the cross-presentation and costimulatory capacity of the tumor-infiltrating DCs. These tumor-Ag-crosspresenting DCs then potentiate tumor-specific CD8+ CTL responses, thereby facilitating tumor regression.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.