Figures & data
Figure 1. Proposed scheme for co-stimulatory signals generated from Notch receptor stimulation on T cells. T cell stimulatory signals can be provided by Notch ligand DLL1 on juxtaposing antigen-presenting cells or by pharmacological DLL1 multivalent cluster in the presence or absence of drugs such as bortezomib. The Notch signal compliments the standard two-signal scheme of T lymphocyte activation, the first from the TCR engagement by its cognate peptide-MHC complex along with the second costimulatory signal from B7/CD28 interaction. Signaling pathways induced by Notch stimulation include canonical and non-canonical cascades resulting in NICD–NF-κB cross-regulation. The resulting activation can impel T cell effector functions necessary for tumor suppression.
