Figures & data
Figure 1. Activated CD8+ T cells with IL-12 conditioning have elevated IL-7Rα and maximal ability to utilize host IL-7 after transfer into a lymphodepleted host. In this schematic diagram, the shaded area indicates theoretical change in host lymphocyte numbers after cytoreductive therapy. As a consequence of lymphodepletion, serum IL-7 levels are greatly and transiently increased (dotted black line). The red lines indicate expression of IL-7Rα on either standard activated (red dotted line) or IL-12-conditioned (red solid line) CD8+ T cells. Unlike standard activated CD8+ T cells, IL-12-conditioned activated CD8+ T cells have elevated IL-7Rα at transfer and can maximally respond to high serum IL-7 levels during the critical lymphopenic window.
