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Reducing prostaglandin E2 production to raise cancer immunogenicity

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Article: e1123370 | Received 17 Nov 2015, Accepted 17 Nov 2015, Published online: 11 May 2016

Figures & data

Figure 1. COX-driven PGE2 production by cancer cells fuels tumor-promoting inflammation and allows progressive tumor growth. Cancer cell-specific COX-deficiency alters the inflammatory profile at the tumor site increasing antitumor mediators and enabling immune-dependent tumor rejection.

Figure 1. COX-driven PGE2 production by cancer cells fuels tumor-promoting inflammation and allows progressive tumor growth. Cancer cell-specific COX-deficiency alters the inflammatory profile at the tumor site increasing antitumor mediators and enabling immune-dependent tumor rejection.