788
Views
5
CrossRef citations to date
0
Altmetric
Author's View

Novel immunotherapy for adult T-cell leukemia/lymphoma: Targeting aurora kinase A

, , &
Article: e1239006 | Received 15 Sep 2016, Accepted 15 Sep 2016, Published online: 07 Oct 2016

Figures & data

Figure 1. (A) Overexpression of AURKA in ATL tumor cells is assumed that epitopes derived from AURKA would largely been presented in the context of particular HLA molecules, reflecting the increased sensitivity of ATL tumor cells to cytocidal activity mediated by AURKA-specific CTLs. (B) AURKA peptide vaccination in combination with adoptive transfer of AURKA-specific TCR-transduced T cells might be able to enhance the durable engraftment of AURKA-specific T cells, which might provide a long-lasting remission of ATL.

Figure 1. (A) Overexpression of AURKA in ATL tumor cells is assumed that epitopes derived from AURKA would largely been presented in the context of particular HLA molecules, reflecting the increased sensitivity of ATL tumor cells to cytocidal activity mediated by AURKA-specific CTLs. (B) AURKA peptide vaccination in combination with adoptive transfer of AURKA-specific TCR-transduced T cells might be able to enhance the durable engraftment of AURKA-specific T cells, which might provide a long-lasting remission of ATL.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.