Figures & data
Figure 1. Summary representation of (A) T-cell co-stimulatory and (B) co-inhibitory molecules of the B7 and TNFR family members.
Figure 2. Amino acid sequence identity comparison of (A) B7 family members and (B) TNFR family members.
Figure 3. Gene alteration frequencies in the B7 and TNFR families across 11 head and neck cancer studies. (A) B7 and TNFR gene alterations. (B) B7 gene alterations. (C) TNFR gene alterations.
Figure 4. Gene alterations and mRNA dysregulation of B7 and TNFR family members in 496 head and neck cancer samples. (A) B7 and TNFR gene alterations and mRNA dysregulation. (B) B7 family member mutation alterations. (C) TNFR family member mutation alterations. (D) B7 family member CNA. (E) TNFR family member CNA. (F) B7 family member mRNA dysregulation. (G) TNFR family member mRNA dysregulation. Each gray box along the X-axis represents each individual.
Figure 5. Correlation between the promoter methylation status and mRNA expression level of the B7 and TNFR families in 496 head and neck cancer samples. Spearman coefficient in red, relatively strong correlation; Spearman coefficient in green, moderate correlation; Spearman coefficient in black, poor correlation. B7-H1 mRNA levels were negatively correlated with promoter methylation status relatively strongly. B7-H3, B7-H4, B7-H5, B7-H6, B7-H7, TNFSF4, TNFRSF5, TNFSF7, TNFSF9, and TNFSF18 mRNA levels were moderately negatively correlated with their promoter methylation status. Promoter methylation status data for TNFRSF14 were unavailable.
Figure 6. B7-H1 is a potential biomarker of head and neck cancer. (A) Overall survival of patients with head and neck cancer with upregulated B7-H1 mRNA. (B) Overall survival of patients with head and neck cancer with upregulated B7-H1, B7-1, or B7-2 mRNA. (C) B7-H1 genetic alteration in four studies from cBioPortal. (D) Increased B7-H1 mRNA in head and neck cancer tissues with B7-H1 amplification. (E) Significant correlation between HPV status and B7-H1 CNA.
