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Review

Novel anti-myeloma immunotherapies targeting the SLAM family of receptors

, , & , MD, Director
Article: e1308618 | Received 08 Feb 2017, Accepted 13 Mar 2017, Published online: 08 May 2017

Figures & data

Table 1. Tissue distribution of SLAM proteins and their ligands.

Figure 1. Different types of SLAM-specific immunotherapies. The figure shows different ways to target the SLAM family of receptors expressed on myeloma cells. The myeloma antigen can be targeted by monoclonal antibodies (mAb), antibody-drug conjugates (ADC), bispecific antibodies, specific T cells recognizing HLA/SLAM peptide complexes, and SLAM-specific chimeric antigen receptor (CAR) T cells.

Figure 1. Different types of SLAM-specific immunotherapies. The figure shows different ways to target the SLAM family of receptors expressed on myeloma cells. The myeloma antigen can be targeted by monoclonal antibodies (mAb), antibody-drug conjugates (ADC), bispecific antibodies, specific T cells recognizing HLA/SLAM peptide complexes, and SLAM-specific chimeric antigen receptor (CAR) T cells.

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