PD-1 related transcriptome profile and clinical outcome in diffuse gliomas

Figures & data

Figure 1. Comparison of PD-1 expression between lower grade gliomas and glioblastoma (GBM) in CGGA (A) and TCGA (B) datasets. PD-1 expression according to IDH mutation status cross grade II to grade IV gliomas in CGGA (C) and TCGA (D) datasets.

Figure 2. PD-1 expression in different molecular subtypes of TCGA transcriptional classification scheme in CGGA (A) and TCGA (B) datasets. ROC curves of PD-1 expression to predict mesenchymal subtype in CGGA (C) and TCGA (D) datasets.

Figure 3. PD-1 related biological process by gene ontology analysis in CGGA (A) and TCGA (B) datasets.

Figure 4. Association between PD-1 expression and immune cell populations in CGGA (A) and TCGA (B) datasets.

Figure 5. Correlation of PD-1 and immune related molecules.

Figure 6. Survival differences of diffuse glioma and GBM patients with high and low PD-1 expression status in CGGA and TCGA datasets.

Table 1. Univariate and multivariate Cox analysis for factors potentially influence overall survival in CGGA and TCGA datasets.

	CGGA (n = 310)			TCGA (n = 597)
Characteristic	p	HR	95%CI	p	HR	95%CI
Univariate
Age	<0.001	1.038	1.023-1.054	<0.001	1.077	1.065-1.090
Grade	<0.001	3.477	2.716-4.452	<0.001	4.897	3.811-6.292
IDH-mut	<0.001	0.244	0.170-0.350	<0.001	0.091	0.064-0.129
PD1	<0.001	2.429	1.743-3.384	<0.001	1.467	1.332-1.616
Multivariate
Age	0.607	1.004	0.989-1.019	<0.001	1.044	1.030-1.059
Grade	<0.001	2.905	2.219 -3.804	<0.001	1.831	1.343-2.498
IDH-mut	0.008	0.572	0.379-0.863	<0.001	0.291	0.176-0.481
PD1	0.031	1.619	1.044-2.512	0.047	1.139	1.002-1.296

Abbreviations: CI, confidence interval; HR, hazard ratio; IDH-mut, IDH mutation status.