Advanced search
Publication Cover
OncoImmunology Volume 7, 2018 - Issue 7
Submit an article Journal homepage
3,107
Views
40
CrossRef citations to date
0
Altmetric
Original Research

TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas

Tsuyoshi HamadaDepartment of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USAView further author information
,
Thing Rinda SoongProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USAView further author information
,
Yohei MasugiDepartment of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USAView further author information
,
Keisuke KosumiDepartment of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USAView further author information
,
Jonathan A. NowakProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USAView further author information
,
Annacarolina da SilvaDepartment of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USAView further author information
,
Xinmeng Jasmine MuDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA;Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USAView further author information
,
Tyler S. TwomblyDepartment of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USAView further author information
,
Hideo KohDepartment of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USAView further author information
,
Juhong YangDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;Collaborative Innovation Center of Tianjin for Medical Epigenetics, Key Laboratory of Hormone and Development, Ministry of Health, Metabolic Disease Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, P.R. ChinaView further author information
,
Mingyang SongClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA;Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA;Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USAView further author information
,
Li LiuDepartment of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Huazhong University of Science and Technology, Hubei, P.R. ChinaView further author information
,
Mancang GuDepartment of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;College of Pharmacy, Zhejiang Chinese Medical University, Zhejiang, P.R. ChinaView further author information
,
Yan ShiDepartment of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;Department of Medical Oncology, Chinese PLA General Hospital, Beijing, P.R. ChinaView further author information
,
Katsuhiko NoshoDepartment of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo, JapanView further author information
,
Teppei MorikawaDepartment of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanView further author information
,
Kentaro InamuraDivision of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, JapanORCID Iconhttp://orcid.org/0000-0001-6444-3861View further author information
ORCID Icon,
Sachet A. ShuklaDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USAView further author information
,
Catherine J. WuDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA;Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USAView further author information
,
Levi A. GarrawayDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA;Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USAView further author information
,
Xuehong ZhangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USAView further author information
,
Kana WuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USAView further author information
,
Jeffrey A. MeyerhardtDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USAView further author information
,
Andrew T. ChanClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA;Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA;Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USAView further author information
,
Jonathan N. GlickmanDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USAView further author information
,
Scott J. RodigDepartment of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USAView further author information
,
Gordon J. FreemanDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USAView further author information
,
Charles S. FuchsYale Cancer Center, New Haven, CT, USA;Department of Medicine, Yale School of Medicine, New Haven, CT, USA;Smilow Cancer Hospital, New Haven, CT, USAView further author information
,
Reiko NishiharaDepartment of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA;Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USAView further author information
,
Marios GiannakisDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA;Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USACorrespondence[email protected]
View further author information
&
Shuji OginoDepartment of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA;Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USACorrespondence[email protected]
View further author information
 show all
Article: e1442999 | Received 12 Dec 2017, Accepted 15 Feb 2018, Published online: 19 Mar 2018

Figures & data

Table 1. Clinical, pathological, and molecular characteristics of colorectal cancer cases according to TIME (Tumor Immunity in the MicroEnvironment) subtypes based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes (TIL).

Figure 1. Kaplan-Meier survival curves of colorectal cancer patients according to TIME (Tumor Immunity in the MicroEnvironment) subtypes based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes (TIL). The p values were calculated using the log-rank test (two-sided). (A), colorectal cancer-specific survival; (B), overall survival.

Figure 1. Kaplan-Meier survival curves of colorectal cancer patients according to TIME (Tumor Immunity in the MicroEnvironment) subtypes based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes (TIL). The p values were calculated using the log-rank test (two-sided). (A), colorectal cancer-specific survival; (B), overall survival.

Table 2. Colorectal cancer survival according to TIME (Tumor Immunity in the MicroEnvironment) subtypes based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes (TIL).

Supplemental material

2017ONCOIMM1013R-s03.docx

Download MS Word (924.1 KB)

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.