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Macrophages in radiation injury: a new therapeutic target

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Article: e1494488 | Received 15 Jun 2018, Accepted 22 Jun 2018, Published online: 23 Jul 2018

Figures & data

Figure 1. Dynamic changes in myeloid cells in the lung after IR. Upper panel: a wave of monocytes is rapidly (3 days post IR, D3) recruited to lung parenchyma, followed by a second wave at day 15 (D15). Interstitial macrophages peak at 6 days (D6) post IR and, after a latent phase, they increase again starting from 16 weeks (W16) after IR. Neutrophil levels are increased at D6-15 before returning to basal. Lower panel: while levels of alveolar neutrophils and monocytes increase at D15 post IR, at this time point, alveolar macrophages are depleted. The levels of the three populations increase again starting from W16.

Figure 1. Dynamic changes in myeloid cells in the lung after IR. Upper panel: a wave of monocytes is rapidly (3 days post IR, D3) recruited to lung parenchyma, followed by a second wave at day 15 (D15). Interstitial macrophages peak at 6 days (D6) post IR and, after a latent phase, they increase again starting from 16 weeks (W16) after IR. Neutrophil levels are increased at D6-15 before returning to basal. Lower panel: while levels of alveolar neutrophils and monocytes increase at D15 post IR, at this time point, alveolar macrophages are depleted. The levels of the three populations increase again starting from W16.