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OncoImmunology Volume 8, 2019 - Issue 7
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Original Research

Molecular and clinical characterization of CD163 expression via large-scale analysis in glioma

Shasha LiuBiotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaView further author information
,
Chaoqi ZhangBiotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China;Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaView further author information
,
Nomathamsanqa Resegofetse MaimelaBiotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaView further author information
,
Li YangBiotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaView further author information
,
Zhen ZhangBiotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China;Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou,Henan, ChinaView further author information
,
Yu PingBiotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaView further author information
,
Lan HuangBiotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaView further author information
&
Yi ZhangBiotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China;Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou,Henan, China;School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China;Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan, ChinaCorrespondence[email protected]
View further author information
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Article: e1601478 | Received 24 Oct 2018, Accepted 22 Mar 2019, Published online: 17 Apr 2019

Figures & data

Figure 1. CD163 was significantly enriched in glioblastoma and in IDH wild-type glioma. (a, b, c) CD163 was highly expressed in glioblastoma (WHO IV) at transcription level. (d, e, f) CD163 was significantly up-regulated in IDH wild-type glioma. *** and **** represent p< 0.001 and p< 0.0001, respectively.

Figure 1. CD163 was significantly enriched in glioblastoma and in IDH wild-type glioma. (a, b, c) CD163 was highly expressed in glioblastoma (WHO IV) at transcription level. (d, e, f) CD163 was significantly up-regulated in IDH wild-type glioma. *** and **** represent p< 0.001 and p< 0.0001, respectively.

Figure 2. CD163 showed a strong expression pattern in mesenchymal molecular subtype glioma. (a, b, c) CD163 was highly enriched in mesenchymal molecular subtype glioma. (d, e, f) CD163 could serve as a biomarker to predict mesenchymal molecular subtype glioma. *, **, and **** represent p < 0.05, p< 0.01, and p< 0.0001, respectively.

Figure 2. CD163 showed a strong expression pattern in mesenchymal molecular subtype glioma. (a, b, c) CD163 was highly enriched in mesenchymal molecular subtype glioma. (d, e, f) CD163 could serve as a biomarker to predict mesenchymal molecular subtype glioma. *, **, and **** represent p < 0.05, p< 0.01, and p< 0.0001, respectively.

Figure 3. CD163 related immune genes and Gene Ontology (GO) terms in glioma. (a, b) CD163 showed a strong positive correlation with most of the immune genes related to GO terms especially in immune response, antigen process presentation, and angiogenesis.

Figure 3. CD163 related immune genes and Gene Ontology (GO) terms in glioma. (a, b) CD163 showed a strong positive correlation with most of the immune genes related to GO terms especially in immune response, antigen process presentation, and angiogenesis.

Figure 4. CD163 was tightly associated with immune score and infiltrated cells in tumor microenvironment. (a and b, upper panel) CD163 was positively related with immune score and stromal score. (a and b, lower panel) CD163 was closely related to infiltrated cells in tumor microenvironment.

Figure 4. CD163 was tightly associated with immune score and infiltrated cells in tumor microenvironment. (a and b, upper panel) CD163 was positively related with immune score and stromal score. (a and b, lower panel) CD163 was closely related to infiltrated cells in tumor microenvironment.

Figure 5. CD163-related inflammatory activities in CGGA database. (a) The heatmap of CD163 related inflammatory metagenes in CGGA cohort. (b) Corrgram of CD163 and inflammatory metagenes in CGGA cohort.

Figure 5. CD163-related inflammatory activities in CGGA database. (a) The heatmap of CD163 related inflammatory metagenes in CGGA cohort. (b) Corrgram of CD163 and inflammatory metagenes in CGGA cohort.

Figure 6. Survival analysis of CD163 in glioma and glioblastoma. (a, b, and c) Survival analysis of CD163 in whole grade glioma. (d, e, and f) Survival analysis of CD163 in glioblastoma.

Figure 6. Survival analysis of CD163 in glioma and glioblastoma. (a, b, and c) Survival analysis of CD163 in whole grade glioma. (d, e, and f) Survival analysis of CD163 in glioblastoma.
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