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OncoImmunology Volume 9, 2020 - Issue 1
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Editorial

Secreted calreticulin mutants subvert anticancer immunosurveillance

Peng Liua Equipe 11 labellisée par la Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France;b Cell Biology and Metabolomics platforms, Gustave Roussy Cancer Campus, Villejuif, France;c UMR1138, INSERM, Paris, France;d Sorbonne Paris Cité, Université Paris Descartes, Paris, France;e Université Pierre et Marie Curie, Paris, France;f Faculty of Medicine, Paris Sud/Paris XI University, Le Kremlin-Bicêtre, FranceORCID Iconhttps://orcid.org/0000-0002-1682-9222
ORCID Icon,
Liwei Zhaoa Equipe 11 labellisée par la Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France;b Cell Biology and Metabolomics platforms, Gustave Roussy Cancer Campus, Villejuif, France;c UMR1138, INSERM, Paris, France;d Sorbonne Paris Cité, Université Paris Descartes, Paris, France;e Université Pierre et Marie Curie, Paris, France;f Faculty of Medicine, Paris Sud/Paris XI University, Le Kremlin-Bicêtre, FranceORCID Iconhttps://orcid.org/0000-0001-5077-327X
ORCID Icon,
Guido Kroemera Equipe 11 labellisée par la Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France;b Cell Biology and Metabolomics platforms, Gustave Roussy Cancer Campus, Villejuif, France;c UMR1138, INSERM, Paris, France;d Sorbonne Paris Cité, Université Paris Descartes, Paris, France;e Université Pierre et Marie Curie, Paris, France;g Center of Systems Medicine, Chinese Academy of Medical Science, Suzhou, China;h Pôle de Biologie, Hôpital Européen Georges Pompidou, Paris, France;i Karolinska Institutet, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, SwedenCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9334-4405
ORCID Icon &
Oliver Keppa Equipe 11 labellisée par la Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France;b Cell Biology and Metabolomics platforms, Gustave Roussy Cancer Campus, Villejuif, France;c UMR1138, INSERM, Paris, France;d Sorbonne Paris Cité, Université Paris Descartes, Paris, France;e Université Pierre et Marie Curie, Paris, France;f Faculty of Medicine, Paris Sud/Paris XI University, Le Kremlin-Bicêtre, FranceCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6081-9558
ORCID Icon
Article: 1708126 | Received 09 Dec 2019, Accepted 19 Dec 2019, Published online: 28 Dec 2019

Figures & data

Figure 1. Immunosuppression by soluble calreticulin. Calreticulin (CALR) can be exposed on the cell surface of cells undergoing immunogenic cell death. Surface-exposed CALR then serves as an uptake signal for dendritic cells (DC), thereby facilitating the transfer of tumor-associated antigens to DC and ultimately the priming of cytotoxic T lymphocytes (CTL) (a). Mutations of the (CALR) gene occur in many forms of cancer and the loss of the KDEL retention signal can lead to the expression of mutant CALR that is secreted from the cells. Extracellular CALR binds to DC and inhibits phagocytosis, presumably by saturating a specific receptor for CALR. Through this mechanism, soluble CALR exerts immunosuppressive effects, hence subverting the effects of anticancer immunotherapy (b)

Figure 1. Immunosuppression by soluble calreticulin. Calreticulin (CALR) can be exposed on the cell surface of cells undergoing immunogenic cell death. Surface-exposed CALR then serves as an uptake signal for dendritic cells (DC), thereby facilitating the transfer of tumor-associated antigens to DC and ultimately the priming of cytotoxic T lymphocytes (CTL) (a). Mutations of the (CALR) gene occur in many forms of cancer and the loss of the KDEL retention signal can lead to the expression of mutant CALR that is secreted from the cells. Extracellular CALR binds to DC and inhibits phagocytosis, presumably by saturating a specific receptor for CALR. Through this mechanism, soluble CALR exerts immunosuppressive effects, hence subverting the effects of anticancer immunotherapy (b)

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