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OncoImmunology Volume 9, 2020 - Issue 1
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Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms

Mrinmoy Dasa Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USAView further author information
,
Emmanuel Stephen-Victora Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USAView further author information
&
Jagadeesh Bayryb Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Equipe - Immunopathologie et Immunointervention Thérapeutique, Sorbonne Université, Université de Paris, Paris, FranceCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0498-9808View further author information
ORCID Icon
Article: 1773193 | Received 19 May 2020, Accepted 20 May 2020, Published online: 05 Jun 2020

Figures & data

Figure 1. Tumor cells secrete chemokines that recruit Treg cells to the tumor microenvironment. Our data suggest that tumor-associated Treg cells promote tumor survival and its immune escape by several mechanisms including secretion of IL-3 to activate basophils and to orchestrate Th2 responses.

Figure 1. Tumor cells secrete chemokines that recruit Treg cells to the tumor microenvironment. Our data suggest that tumor-associated Treg cells promote tumor survival and its immune escape by several mechanisms including secretion of IL-3 to activate basophils and to orchestrate Th2 responses.

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