Tropomyosin autoantibodies associated with checkpoint inhibitor myositis

Figures & data

Figure 1. Comparison of IgA and IgG levels to tropomyosin isoforms 1, 2 and 3 in the reported clinical case study. IgA levels from the sera of a group of metastatic melanoma patients without myositis (n = 100) at baseline prior to undergoing immunotherapy are also illustrated. Levels are presented as Log2 fold changes (log2FC) and were calculated by dividing the case signal intensity for each antigen by the mean case signal intensity of all antigens or the median signal intensity of all antigens across the cohort of other metastatic melanoma samples. The horizontal line at log2FC = 3.47 represents the cutoff where the case Z score > 3, indicating a positive signal intensity.

Table

Name	Location	Role	Contribution
Pauline Zaenker, PhD	Edith Cowan University, Perth	Author	Design and conceptualized study; Data collection and analysis, drafted the manuscript for intellectual content
David Prentice, MD	St John of God Midland Public Hospital, Midland	Author	Design and conceptualized study; Data collection and analysis, Drafting and revision for intellectual content
Melanie Ziman, PhD	Edith Cowan University and the University of Western Australia, Perth	Author	Design and conceptualized study; Drafting and revision for intellectual content