Figures & data
Figure 1. Immune heterogeneity of metatastic colorectal cancer. A high T cell infiltration and Immunoscore measured in the least-infiltrated metastasis were associated with a significantly lower number of metastases, larger metastasis, and prolonged survival while patients with increased metastatic burden had a lower Immunoscore. Immunoscore evaluated in a random biopsy or in a random metastasis or as the mean value of all metastases significantly predicting outcome. The most immune infiltrated metastasis (Max) was not significantly predicting outcome, whereas the least immune infiltrated metastasis (Min) was best in predicting clinical outcome. Receiver operating characteristics likelihood of concordance of biomarkers (Immunoscore and PD-L1) between biopsy and complete metastasis evaluation, shows better performance for Immunoscore. Preoperative treatment containing anti-EGFR monoclonal antibody is associated with increase T cell densities in the core of the metastases.
